Optical coherence tomography (OCT) Potential of a new high-resolution intracoronary imaging technique

被引:0
作者
Gerckens, U
Buellesfeld, L
McNamara, E
Grube, E
机构
[1] Klinikum Siegburg Rhein Sieg GmbH, Ctr Heart, Dept Cardiol & Angiol, D-53721 Siegburg, Germany
[2] LightLab Imaging, Westford, MA USA
关键词
OCT; vulnerable plaque; coronary heart disease; imaging technique;
D O I
10.1007/s00059-003-2485-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: It is believed that most myocardial infarctions result from the rupture of "vulnerable plaques", that share certain common characteristics. These plaques typically consist of a lipid-rich core in the central portion of the thickened intima, covered by a thin friable fibrous cap. Today, one of the important challenges in the field of interventional cardiology is how to identify minor or silent plaques that carry the risk of thrombosis resulting in severe cardiac events. Current imaging technologies lack the resolution to reliably identify these lesions. OCT: Optical Coherence Tomography (OCT) might have the potential to fill this role. OCT is a new non-contact, light-based imaging modality providing in situ images of tissues at near histologic resolution. As shown in various preclinical and clinical reports, OCT allows the identification of mural as well as luminal morphologies including lumen dimensions, plaques, thrombi, dissections, tissue flaps as well as information on stent geometries including apposition and symmetry. Trials comparing intravascular ultrasound (IVUS) and OCT demonstrated that OCT provided additional morphologic information, which could be used to improve plaque characterization. Conclusion: OCT has the potential to provide a new and more detailed look into the vessel wall, which might help to identify plaques that are at risk of rupture, and furthermore, which will influence and guide the appropriate patient-specific therapeutic approach.
引用
收藏
页码:496 / 500
页数:5
相关论文
共 8 条
[1]   Evaluation of intracoronary stenting by intravascular optical coherence tomography [J].
Bouma, BE ;
Tearney, GJ ;
Yabushita, H ;
Shishkov, M ;
Kauffman, CR ;
Gauthier, DD ;
MacNeill, BD ;
Houser, SL ;
Aretz, HT ;
Halpern, EF ;
Jang, IK .
HEART, 2003, 89 (03) :317-320
[2]   Imaging of coronary artery microstructure (in vitro) with optical coherence tomography [J].
Brezinski, ME ;
Tearney, GJ ;
Bouma, BE ;
Boppart, SA ;
Hee, MR ;
Swanson, EA ;
Southern, JF ;
Fujimoto, JG .
AMERICAN JOURNAL OF CARDIOLOGY, 1996, 77 (01) :92-93
[3]   Optical coherence tomography for optical biopsy - Properties and demonstration of vascular pathology [J].
Brezinski, ME ;
Tearney, GJ ;
Bouma, BE ;
Izatt, JA ;
Hee, MR ;
Swanson, EA ;
Southern, JF ;
Fujimoto, JG .
CIRCULATION, 1996, 93 (06) :1206-1213
[4]   Intracoronary imaging with optical coherence tomography - A new high-resolution technology providing striking visualization in the coronary artery [J].
Grube, E ;
Gerckens, U ;
Buellesfeld, L ;
Fitzgerald, PJ .
CIRCULATION, 2002, 106 (18) :2409-2410
[5]   Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound [J].
Jang, IK ;
Bouma, BE ;
Kang, DH ;
Park, SJ ;
Park, SW ;
Seung, KB ;
Choi, KB ;
Shishkov, M ;
Schlendorf, K ;
Pomerantsev, E ;
Houser, SL ;
Aretz, HT ;
Tearney, GJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (04) :604-609
[6]   Visualization of tissue prolapse between coronary stent struts by optical coherence tomography - Comparison with intravascular ultrasound [J].
Jang, IK ;
Tearney, G ;
Bouma, B .
CIRCULATION, 2001, 104 (22) :2754-2754
[7]   Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound [J].
Patwari, P ;
Weissman, NJ ;
Boppart, SA ;
Jesser, C ;
Stamper, D ;
Fujimoto, JG ;
Brezinski, ME .
AMERICAN JOURNAL OF CARDIOLOGY, 2000, 85 (05) :641-644
[8]   Characterization of human atherosclerosis by optical coherence tomography [J].
Yabushita, H ;
Bourna, BE ;
Houser, SL ;
Aretz, T ;
Jang, IK ;
Schlendorf, KH ;
Kauffman, CR ;
Shishkov, M ;
Kang, DH ;
Halpern, EF ;
Tearney, GJ .
CIRCULATION, 2002, 106 (13) :1640-1645