A phytochemically characterized extract of Cordyceps militaris and cordycepin protect hippocampal neurons from ischemic injury in gerbils

被引：46

作者：

Hwang, In Koo ^{[2
,3
]}

Lim, Soon Sung ^{[4
]}

Yoo, Ki-Yeon ^{[1
]}

Lee, Yeon Sil ^{[4
]}

Kim, Ho Gyoung ^{[5
]}

Kang, Ii-Jun ^{[6
]}

Kwon, Hyung Joo ^{[7
]}

Park, Jinseu ^{[8
,9
]}

Choi, Soo Young ^{[8
,9
]}

Won, Moo-Ho ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Inst Neurodegenerat & Regenerat, Dept Anat & Neurobiol, Chunchon 200702, South Korea

[2] Seoul Natl Univ, Coll Vet Med, Dept Anat & Cell Biol, Seoul, South Korea

[3] Seoul Natl Univ, BK21 Program Vet Sci, Seoul, South Korea

[4] Hallym Univ, Reg Innovat Ctr, Chunchon, South Korea

[5] Mushtech Co Ltd, Chunchon, South Korea

[6] Hallym Univ, Dept Food Sci & Nutr, Chunchon 200702, South Korea

[7] Hallym Univ, Coll Med, Dept Microbiol, Chunchon 200702, South Korea

[8] Hallym Univ, Dept Biomed Sci, Chunchon 200702, South Korea

[9] Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 200702, South Korea

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

neuroprotection; ischemia; pyramidal neurons; hippocampus; Cordyceps militaris; cordycepin; fungus;

D O I：

10.1055/s-2008-1034277

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the present study, we investigated effects of the dried, hot-water extract of Cordyceps militaris (CME) and its major metabolite (cordycepin) against ischemic damage. The repeated treatment with CME protected hippocampal CA1 pyramidal neurons from ischemic damage in gerbils. The treatment with CME or cordycepin in gerbils reduced 4-hydroxy-2-nonenal (a marker of lipid peroxidation) immunoreactivity and levels in the ischemic CA1 region. Glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 immunoreactive microglia in the vehicle-treated ischemic group were activated in the CA1 region 4 days after ischemia/reperfusion, whereas in the CME- or cordycepin-treated ischemic group, their activation was significantly decreased. These results suggest that the repeated treatment with CME protects against neuronal damage from ischemia/reperfusion by reducing oxidative damage.

引用

页码：114 / 119

页数：6

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