Correlation between S100B and severity of depression in MDD: A meta-analysis

被引:18
|
作者
Tural, Umit [1 ]
Irvin, Molly Kennedy [1 ]
Iosifescu, Dan Vlad [1 ,2 ]
机构
[1] Nathan S Kline Inst Psychiat Res, Clin Res Div, Orangeburg, NY USA
[2] NYU, Sch Med, Psychiatry Dept, New York, NY USA
来源
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2022年 / 23卷 / 06期
关键词
Major depressive disorder; S100B; meta-analysis; glia; correlation; NEURON-SPECIFIC ENOLASE; SERUM S100B; ELECTROCONVULSIVE-THERAPY; PREFRONTAL CORTEX; MOOD DISORDERS; PROTEIN; S-100B; SCHIZOPHRENIA; BIOMARKERS; PATHOLOGY;
D O I
10.1080/15622975.2021.2013042
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Previous studies have demonstrated elevated levels of the S100B protein (located in glial cells) in major depressive disorder (MDD) as compared to healthy controls. However, studies reporting correlation between S100B levels and depression severity have been conflicting. Methods We investigated, through systematic review and meta-analysis, whether the correlation between S100B levels and depression severity is significant in patients with MDD. Pearson correlation coefficients reported in the individual studies were converted to Fisher's Z scores, then pooled using the random effects model. Meta-regression was used to test modifiers of the effect size. Results Sixteen studies including 658 patients with MDD met eligibility criteria. No publication bias was observed. There was a significant and positive correlation between serum S100B level and depression severity (r = 0.204, z = 2.297, p = 0.022). A meta-regression determined that onset age of MDD and percentage of female participants are significant modifiers of this correlation. A moderate, but non-significant heterogeneity was observed in serum studies (44%). Conclusion As many studies have reported significantly increased levels of S100B in MDD compared to controls, this meta-analysis supports the assumption that the increase in S100B correlates with the severity of MDD. Additional studies investigating the precise biological connection between S100B and MDD are indicated.
引用
收藏
页码:456 / 463
页数:8
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