Mechanisms and disease relevance of neutrophil extracellular trap formation

被引:45
|
作者
Van Avondt, Kristof [1 ,2 ]
Hartl, Dominik [3 ]
机构
[1] Sanquin Res, Dept Immunopathol, Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, Amsterdam, Netherlands
[3] Univ Tubingen, Childrens Hosp, Tubingen, Germany
关键词
inflammation; neutrophil extracellular traps; neutrophils; PEPTIDYLARGININE DEIMINASE INHIBITION; PAPILLON-LEFEVRE SYNDROME; NET FORMATION; MITOCHONDRIAL-DNA; DENDRITIC CELLS; RELEASE; NETOSIS; STREPTOCOCCUS; ARTHRITIS; RESPONSES;
D O I
10.1111/eci.12919
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
While the microscopic appearance of neutrophil extracellular traps (NETs) has fascinated basic researchers since its discovery, the (patho)physiological mechanisms triggering NET release, the disease relevance and clinical translatability of this unconventional cellular mechanism remained poorly understood. Here, we summarize and discuss current concepts of the mechanisms and disease relevance of NET formation.
引用
收藏
页数:10
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