An improved synthesis of pyridoxine via [2+2+2] cyclization of acetylenes and nitriles

被引：19

作者：

Gutnov, A

Abaev, V

Redkin, D

Fischer, C

Bonrath, W

Heller, B

机构：

[1] Univ Rostock eV, Leibinz Inst Organ Katalyse, D-18055 Rostock, Germany

[2] DSM Nutr Prod Ltd, CH-4303 Kaiseraugst, Switzerland

来源：

SYNLETT | 2005年 / 07期

关键词：

pyridines; alkynes; nitriles; cyclizations; vitamins;

D O I：

10.1055/s-2005-864834

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved synthesis of pyridoxine (vitamin B-6) is reported. The key step involves the light-promoted [2+2+2] cyclization of 3,3-bissilyl-di-2-propynyl ethers and acetonitrile in the presence of [cpCo(cod)] (1 mol%) as a catalyst. Convenient oxidation and iodination procedures are elaborated to transfer 3-silyl-pyridines into corresponding 3-hydroxy- and 3-iodo-derivatives.

引用

页码：1188 / 1190

页数：3

共 17 条

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