Regulation of virulence gene expression in Streptococcus pyogenes Determinants of differential mRNA decay

被引：12

作者：

Bugrysheva, Julia V. ^{[1
]}

Scott, June R. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

RNA BIOLOGY | 2010年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Streptococcus pyogenes; mRNA stability; mRNA decay; RNase J1; RNase J2; PNPase; growth phase control; GROUP-A STREPTOCOCCI; PATHOGENESIS; ELEMENTS; CHILDREN; GROWTH; SYSTEM; MODEL; J1;

D O I：

10.4161/rna.7.5.13097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by (1) stability in the stationary phase of growth, (2) kinetics of decay in exponential phase and (3) effect of depletion of RNases J1 and J2 and polynucleotide phosphorylase (PNPase) on decay in exponential phase. We discuss features of the structure of an mRNA that appear to be important for determining the Class to which it belongs and present a model to explain differential mRNA decay.

引用

页码：569 / 572

页数：4

共 23 条

[1]

Arnold TE, 1998, RNA, V4, P319

[2] The yeast Apq12 protein affects nucleocytoplasmic mRNA transport [J].

Baker, KE ;

Coller, J ;

Parker, R .

RNA, 2004, 10 (09) :1352-1358

[3] Role of mRNA stability in growth phase regulation of gene expression in the group A streptococcus [J].

Barnett, Timothy C. ;

Bugrysheva, Julia V. ;

Scott, June R. .

JOURNAL OF BACTERIOLOGY, 2007, 189 (05) :1866-1873

[4] Sensitive detection of bacterial transcription initiation sites and differentiation from RNA processing sites in the pheromone-induced plasmid transfer system of Enterococcus faecalis [J].

Bensing, BA ;

Meyer, BJ ;

Dunny, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7794-7799

[5] The ribonucleases J1 and J2 are essential for growth and have independent roles in mRNA decay in Streptococcus pyogenes [J].

Bugrysheva, Julia V. ;

Scott, June R. .

MOLECULAR MICROBIOLOGY, 2010, 75 (03) :731-743

[6] The global burden of group A streptococcal diseases [J].

Carapetis, JR ;

Steer, AC ;

Mulholland, EK ;

Weber, M .

LANCET INFECTIOUS DISEASES, 2005, 5 (11) :685-694

[7]

Cunningham MW, 2008, ADV EXP MED BIOL, V609, P29, DOI 10.1007/978-0-387-73960-1_3

[8] Lost in translation: the influence of ribosomes on bacterial mRNA decay [J].

Deana, A ;

Belasco, JG .

GENES & DEVELOPMENT, 2005, 19 (21) :2526-2533

[9] Ribonucleases J1 and J2:: two novel endoribonucleases in B.subtilis with functional homology to E.coli RNase E [J].

Even, S ;

Pellegrini, O ;

Zig, L ;

Labas, V ;

Vinh, J ;

Bréchemmier-Baey, D ;

Putzer, H .

NUCLEIC ACIDS RESEARCH, 2005, 33 (07) :2141-2152

[10] Structure, regulation, and putative function of the arginine deiminase system of Streptococcus suis [J].

Gruening, P ;

Fulde, M ;

Valentin-Weigand, P ;

Goethe, R .

JOURNAL OF BACTERIOLOGY, 2006, 188 (02) :361-369

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