Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters

被引:7
作者
Van Hoey, Olivier [1 ]
Stolarczyk, Liliana [2 ,3 ,4 ]
Lillhoek, Jan [5 ]
Eliasson, Linda [6 ]
Mojzeszek, Natalia [3 ]
Liszka, Malgorzata [3 ,4 ]
Alkhiat, Ali [4 ,7 ]
Mares, Vladimir [8 ]
Trompier, Francois [9 ]
Trinkl, Sebastian [8 ,10 ]
Martinez-Rovira, Immaculada [11 ]
Romero-Exposito, Maite [11 ]
Domingo, Carles [11 ]
Ploc, Ondrej [12 ]
Harrison, Roger [13 ]
Olko, Pawel [3 ]
机构
[1] Belgian Nucl Res Ctr SCK CEN, Inst Environm, Hlth & Safety EHS, Mol, Belgium
[2] Aarhus Univ Hosp AUH, Danish Ctr Particle Therapy, Aarhus, Denmark
[3] Inst Nucl Phys, Polish Acad Sci, IFJ PAN, Krakow, Poland
[4] Skandion Clin, Uppsala, Sweden
[5] Swedish Radiat Safety Author, Solna, Sweden
[6] Royal Inst Technol KTH, Dept Phys, Stockholm, Sweden
[7] Karolinska Univ Hosp, Dept Med Radiat Phys & Nucl Med, Stockholm, Sweden
[8] Helmholtz Zentrum Munchen, Inst Radiat Med, Neuherberg, Germany
[9] Inst Radioprotect & Surete Nucl IRSN, PSE Sante, Fontenay aux roses, France
[10] Fed Off Radiat Protect, Neuherberg, Germany
[11] Univ Autonoma Barcelona, Dept Fis, Bellaterra, Spain
[12] Czech Acad Sci CAS, Dept Radiat Dosimetry, Nucl Phys Inst, Prague, Czech Republic
[13] Univ Newcastle Tyne, Fac Med Sci, Newcastle Upon Tyne, England
来源
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词
Proton therapy; Pencil beam scanned proton therapy; Neutron doses; Monte Carlo simulations; Out-of-field neutron doses in radiation therapy; Neutron measurements; FIELD; SPECTROMETRY; RADIATION; DOSIMETRY; COUNTERS;
D O I
10.3389/fonc.2022.903537
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities.
引用
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页数:22
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