Possible implications of arginase and diamine oxidase in prostatic carcinoma

被引:0
作者
Keskinege, A
Elgün, S [1 ]
Yilmaz, E
机构
[1] Ankara Univ, Tip Fak Biyokimya ABD, Dept Biochem & Clin Chem, Dekanlik Binasi, TR-06100 Ankara, Turkey
[2] Ankara Univ, Duzen Labs Grp, TR-06100 Ankara, Turkey
[3] Ankara Univ, Dept Urol, TR-06100 Ankara, Turkey
来源
CANCER DETECTION AND PREVENTION | 2001年 / 25卷 / 01期
关键词
arginase; benign prostatic hyperplasia; diamine oxidase; prostate cancer;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Polyamine metabolism in prostatic tissue, which may give rise to prostatic hyperplasia by inducing cell proliferation, is controlled primarily by two enzymes: arginase and diamine oxidase (DAO). Arginase catalyzes the synthesis of ornithine, the precursor for polyamines from arginine, whereas DAO catalyzes the oxidation of diamines, such as spermine and spermidine, to a much less active compound called putrescine. In this study, we evaluated arginase and DAO activities in prostate tissues of 50 patients with benign prostatic hyperplasia and in 23 patients with prostatic carcinoma. Both DAO and arginase activities were found to be elevated in cancer tissues as compared to benign prostatic hyperplasia (fivefold and twofold, respectively; P < .001). A strong inverse correlation between arginase and DAO activities was observed in those in the cancer group (r = -0.65; P <.001). Gleason grades of prostatic carcinomas were well correlated with both arginase and DAO activities. Results suggest that DAO and arginase might play an essential role in the mechanism of prostatic disease process by modulating polyamine levels.
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页码:76 / 79
页数:4
相关论文
共 22 条
[1]   DIAMINEOXIDASE ACTIVITY AND TISSUE HISTAMINE CONTENT OF HUMAN-SKIN, BREAST AND RECTAL-CARCINOMA [J].
CHANDA, R ;
GANGULY, AK .
CANCER LETTERS, 1987, 34 (02) :207-212
[2]  
CHINARD FP, 1952, J BIOL CHEM, V199, P91
[3]  
CIPOLLA B, 1993, EUR UROL, V24, P124
[4]   ORNITHINE DECARBOXYLASE AND DIAMINE OXIDASE IN HUMAN-COLON CARCINOMA CELL-LINE CACO-2 IN CULTURE [J].
DAGOSTINO, L ;
DANIELE, B ;
PIGNATA, S ;
GENTILE, R ;
TAGLIAFERRI, P ;
CONTEGIACOMO, A ;
SILVESTRO, G ;
POLISTINA, C ;
BIANCO, AR ;
MAZZACCA, G .
GASTROENTEROLOGY, 1989, 97 (04) :888-894
[5]  
HARRIS BE, 1983, CANCER RES, V43, P3008
[6]   SPERMIDINE AND SPERMINE IN RAT TISSUES AT DIFFERENT AGES [J].
JANNE, J ;
RAINA, A ;
SIIMES, M .
ACTA PHYSIOLOGICA SCANDINAVICA, 1964, 62 (04) :352-+
[7]  
KUSCHE J, 1986, CANCER DETECT PREV, V9, P17
[8]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[9]  
MELLERUP B, 1967, CLIN CHEM, V13, P900
[10]   LARGE BOWEL TUMORS AND DIAMINE OXIDASE (DAO) ACTIVITY IN PATIENTS - A NEW APPROACH FOR RISK GROUP IDENTIFICATION [J].
MENNIGEN, R ;
KUSCHE, J ;
KRAKAMP, B ;
ELBERS, A ;
AMOEI, B ;
KESSEBOHM, M ;
SOMMER, H .
AGENTS AND ACTIONS, 1988, 23 (3-4) :351-353