Solubility of celecoxib in 1-propanol + water mixtures at T= (293.2-313.2) K: experimental data and thermodynamic analysis

The molar solubility of celecoxib (CXB) was measured in the binary mixtures of 1-propanol + water at temperatures ranging from 293.2 to 313.2 K. The obtained solubility data are mathematically represented by employing five cosolvency models (i.e. van't Hoff equation, Yalkowsky-Roseman model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model and the modified Wilson model), and the mean relative deviations (MRD%) calculated for the back-calculated solubility data were 2.5%, 68.7%, 12.7%, 12.8% and 20.5%, respectively, for each investigated cosolvency model. The apparent dissolution enthalpy, entropy and Gibbs energy of CXB in these solvent mixtures were also computed based on the van't Hoff and Gibbs equations.