Hemorrhage Rates and Outcomes when Using up to 100 mg Intra-Arterial t-PA for Thrombolysis in Acute Ischemic Stroke

被引：11
作者：
Christoforidis, G. A. [1 ]
Slivka, A. P. [2 ]
Karakasis, C. [3 ]
Mohammad, Y. [4 ]
Avutu, B. [3 ]
Yang, M. [3 ]
Bourekas, E. C. [3 ]
Chakeres, D. W. [3 ]
Slone, H. W. [3 ]
Yuk, Wt [3 ]
机构：
[1] Univ Chicago, Med Ctr, Dept Radiol, Sch Med, Chicago, IL 60601 USA
[2] Ohio State Univ, Coll Med, Dept Neurol, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Radiol, Coll Med, Columbus, OH 43210 USA
[4] Rush Univ, Dept Neurol, Chicago, IL 60612 USA
来源：
INTERVENTIONAL NEURORADIOLOGY | 2010年 / 16卷 / 03期
关键词：
thrombolytic therapy; intracerebral hemorrhage; acute ischemic stroke; TISSUE-PLASMINOGEN-ACTIVATOR; RANDOMIZED CONTROLLED-TRIAL; COOPERATIVE ACUTE STROKE; CEREBRAL-ARTERY STROKE; INTRACEREBRAL HEMORRHAGE; INTRACRANIAL HEMORRHAGE; PROGNOSTIC VALUE; PROACT II; THERAPY; TRANSFORMATION;
D O I：
10.1177/159101991001600312
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This work presents a unique single center experience with intra-arterial delivery of tissue plasminogen activator (t-PA) doses as high as 100mg for thrombolysis Hemorrhage volumes, hemorrhage rates, clinical outcomes and radiographic outcomes were assessed
引用
收藏
页码：297 / 305
页数：9
相关论文
共 35 条
[1]   ATLANTIS trial - Results for patients treated within 3 hours of stroke onset [J].
Albers, GW ;
Clark, WM ;
Madden, KP ;
Hamilton, SA .
STROKE, 2002, 33 (02) :493-495
[2]   Markedly reduced apparent blood volume on bolus contrast magnetic resonance imaging as a predictor of hemorrhage after thrombolytic therapy for acute ischemic stroke [J].
Alsop, DC ;
Makovetskaya, E ;
Kumar, S ;
Selim, M ;
Schlaug, G .
STROKE, 2005, 36 (04) :746-750
[3]  
[Anonymous], NEW ENGL J MED
[4]   TREATMENT OF ACUTE ISCHEMIC STROKE - CHALLENGING THE CONCEPT OF A RIGID AND UNIVERSAL TIME WINDOW [J].
BARON, JC ;
VONKUMMER, R ;
DELZOPPO, GJ .
STROKE, 1995, 26 (12) :2219-2221
[5]   Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke [J].
Brott, T ;
Broderick, J ;
Kothari, R ;
ODonoghue, M ;
Barsan, W ;
Tomsick, T ;
Spilker, J ;
Miller, R ;
Sauerbeck, L ;
Farrell, J ;
Kelly, J ;
Perkins, T ;
Miller, R ;
McDonald, T ;
Rorick, M ;
Hickey, C ;
Armitage, J ;
Perry, C ;
Thalinger, K ;
Rhude, R ;
Schill, J ;
Becker, PS ;
Heath, RS ;
Adams, D ;
Reed, R ;
Klei, M ;
Hughes, A ;
Anthony, J ;
Baudendistel, D ;
Zadicoff, C ;
Rymer, M ;
Bettinger, I ;
Laubinger, P ;
Schmerler, M ;
Meiros, G ;
Lyden, P ;
Dunford, J ;
Zivin, J ;
Rapp, K ;
Babcock, T ;
Daum, P ;
Persona, D ;
Brody, M ;
Jackson, C ;
Lewis, S ;
Liss, J ;
Mahdavi, Z ;
Rothrock, J ;
Tom, T ;
Zweifler, R .
STROKE, 1997, 28 (11) :2109-2118
[6]   Predictors of Hemorrhage Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Role of Pial Collateral Formation [J].
Christoforidis, G. A. ;
Karakasis, C. ;
Mohammad, Y. ;
Caragine, L. P. ;
Yang, M. ;
Slivka, A. P. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2009, 30 (01) :165-170
[7]  
Christoforidis GA, 2005, AM J NEURORADIOL, V26, P1789
[8]   Size matters - Hemorrhage volume as an objective measure to define significant intracranial hemorrhage associated with thrombolysis [J].
Christoforidis, Gregory A. ;
Slivka, Andrew ;
Mohammad, Yousef ;
Karakasis, Christopher ;
Avutu, Bindu ;
Yang, Ming .
STROKE, 2007, 38 (06) :1799-1804
[9]   Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset - The ATLANTIS study: A randomized controlled trial [J].
Clark, WM ;
Wissman, S ;
Albers, GW ;
Jhamandas, JH ;
Madden, KP ;
Hamilton, S .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (21) :2019-2026
[10]   PROACT: A phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke [J].
del Zoppo, GJ ;
Higashida, RT ;
Furlan, AJ ;
Pessin, MS ;
Rowley, HA ;
Gent, M .
STROKE, 1998, 29 (01) :4-11
1234