Biosynthesis of Beta vulgaris mediated ZnO Nanoparticles and their Anti-bacterial, Anti-fungal, Anti-diabetic and Anti-cancer Activities

Plant extract mediated metal or metal oxide nanoparticles is a promising alternate to the chemical and physical methods. Application of nanoparticles in various fields get increased widely due to their properties. Current study involves the eco-friendly method of synthesis and pharmacological applications of zinc oxide nanoparticles (ZnO-NPs) using the aqueous beetroot (Beta vulgaris) extract. Aqueous Beta vulgaris extract has multiple bio-active phytochemicals especially antioxidants like anthocyanins and betacyanins, also reported a rich source of minerals. Synthesized ZnONPs were characterized with the aid of UV-Vis spectroscopy, FTIR, SEM, XRD and EDX. Antibacterial results suggests that, Beta vulgaris mediated ZnONPs possessthe maximum zone of inhibition against Escherichia colithen Staphylococcus aureus. On anti-fungal activity synthesized ZnONPS revealed greater inhibitory effect against Candida albicans fungi than the Aspergillus flavus. Synthesized ZnONPs exhibits the noticeable pharmacological activities against the anti-diabetic and anti-cancer activities (MCF-7 cell line, IC50=35.4 mu g/mL). This study has suggested an effective replacement for the hazardous chemical methods and lead to a cost-effective, environmentally-friendly method which can also be used as an antimicrobial, anti-diabetic and anti-cancer agents.