Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases

被引：35

作者：

Caldeira, Dayene de Assis Fernandes ^{[1
]}

Weiss, Daniel J. ^{[2
]}

Rocco, Patricia Rieken Macedo ^{[1
,3
,4
]}

Silva, Pedro Leme ^{[1
,3
,4
]}

Cruz, Fernanda Ferreira ^{[1
,3
,4
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biophys Carlos Chagas Filho, Lab Pulm Invest, Rio De Janeiro, Brazil

[2] Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA

[3] Natl Inst Sci & Technol Regenerat Med, Rio De Janeiro, Brazil

[4] Rio De Janeiro Innovat Network Nanosyst Hlth Nano, Rio De Janeiro, Brazil

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

mitochondrial dysfunction; mitochondrial dynamics; mitochondrial morphology; mitotherapy; chronic lung diseases; reactive species of oxygen (ROS); OBSTRUCTIVE PULMONARY-DISEASE; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; DIESEL EXHAUST PARTICLES; AIRWAY EPITHELIAL-CELLS; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS; SENESCENCE IMPLICATIONS; N-ACETYLCYSTEINE; CONTACT SITES;

D O I：

10.3389/fimmu.2021.782074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitochondria are essential organelles for cell metabolism, growth, and function. Mitochondria in lung cells have important roles in regulating surfactant production, mucociliary function, mucus secretion, senescence, immunologic defense, and regeneration. Disruption in mitochondrial physiology can be the central point in several pathophysiologic pathways of chronic lung diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and asthma. In this review, we summarize how mitochondria morphology, dynamics, redox signaling, mitophagy, and interaction with the endoplasmic reticulum are involved in chronic lung diseases and highlight strategies focused on mitochondrial therapy (mito-therapy) that could be tested as a potential therapeutic target for lung diseases.

引用

页数：15

共 183 条

[1] Differential regulation of autophagy and mitophagy in pulmonary diseases [J].

Aggarwal, Saurabh ;

Mannam, Praveen ;

Zhang, Jianhua .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 311 (02) :L433-L452

[2] Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease [J].

Aghapour, Mahyar ;

Remels, Alexander H., V ;

Pouwels, Simon D. ;

Bruder, Dunja ;

Hiemstra, Pieter S. ;

Cloonan, Suzanne M. ;

Heijink, Irene H. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2020, 318 (01) :L149-L164

[3] Mitochondrial Dysfunction Increases Allergic Airway Inflammation [J].

Aguilera-Aguirre, Leopoldo ;

Bacsi, Attila ;

Saavedra-Molina, Alfredo ;

Kurosky, Alexander ;

Sur, Sanjiv ;

Boldogh, Istvan .

JOURNAL OF IMMUNOLOGY, 2009, 183 (08) :5379-5387

[4] Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease [J].

Ahmad, Tanveer ;

Sundar, Isaac K. ;

Lerner, Chad A. ;

Gerloff, Janice ;

Tormos, Ana M. ;

Yao, Hongwei ;

Rahman, Irfan .

FASEB JOURNAL, 2015, 29 (07) :2912-2929

[5] Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy [J].

Ahmad, Tanveer ;

Mukherjee, Shravani ;

Pattnaik, Bijay ;

Kumar, Manish ;

Singh, Suchita ;

Kumar, Manish ;

Rehman, Rakhshinda ;

Tiwari, Brijendra K. ;

Jha, Kumar A. ;

Barhanpurkar, Amruta P. ;

Wani, Mohan R. ;

Roy, Soumya S. ;

Mabalirajan, Ulaganathan ;

Ghosh, Balaram ;

Agrawal, Anurag .

EMBO JOURNAL, 2014, 33 (09) :994-1010

[6] Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers [J].

Aksoy, Mark O. ;

Kim, Victor ;

Cornwell, William D. ;

Rogers, Thomas J. ;

Kosmider, Beata ;

Bahmed, Karim ;

Barrero, Carlos ;

Merali, Salim ;

Shetty, Neena ;

Kelsen, Steven G. .

RESPIRATORY RESEARCH, 2017, 18

[7] Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription [J].

Al-Mehdi, Abu-Bakr ;

Pastukh, Viktor M. ;

Swiger, Brad M. ;

Reed, Darla J. ;

Patel, Mita R. ;

Bardwell, Gina C. ;

Pastukh, Viktoriya V. ;

Alexeyev, Mikhail F. ;

Gillespie, Mark N. .

SCIENCE SIGNALING, 2012, 5 (231)

[8] Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics [J].

Aldridge, RE ;

Chan, T ;

Van Dalen, CJ ;

Senthilmohan, R ;

Winn, M ;

Venge, P ;

Town, GI ;

Kettle, AJ .

FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (06) :847-856

[9] IPF lung fibroblasts have a senescent phenotype [J].

Alvarez, Diana ;

Cardenes, Nayra ;

Sellares, Jacobo ;

Bueno, Marta ;

Corey, Catherine ;

Hanumanthu, Vidya Sagar ;

Peng, Yating ;

D'Cunha, Hannah ;

Sembrat, John ;

Nouraie, Mehdi ;

Shanker, Swaroop ;

Caufield, Chandler ;

Shiva, Sruti ;

Armanios, Mary ;

Mora, Ana L. ;

Rojas, Mauricio .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2017, 313 (06) :L1164-L1173

[10] Mesenchymal stromal cell therapy in COPD: from bench to bedside [J].

Antunes, Mariana A. ;

Lapa e Silva, Jose Roberto ;

Rocco, Patricia R. M. .

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2017, 12 :3017-3027

← 1 2 3 4 5 6 7 8 9 10 →