Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients

被引：20
作者：
Chew, C. S. N.
Cherry, C. L. [2 ,3 ,4 ]
Imran, D. [5 ]
Yunihastuti, E. [5 ]
Kamarulzaman, A. [6 ]
Varna, S. [6 ]
Ismail, R. [7 ]
Phipps, M. [8 ]
Aghafar, Z.
Gut, I. [9 ]
Price, P. [1 ]
机构：
[1] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia
[2] Ctr Virol, Melbourne, Vic, Australia
[3] Alfred Hosp, Infect Dis Unit, Melbourne, Vic, Australia
[4] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia
[5] Univ Indonesia, Pokdisus Working Grp AIDS, Fac Med, Cipto Mangunkusumo Hosp, Jakarta, Indonesia
[6] Univ Malaya, Fac Med, Ctr Excellence Res AIDS CERiA, Kuala Lumpur, Malaysia
[7] Univ Sains Malaysia, Inst Res Mol Med, Kubang Kerian, Kelantan, Malaysia
[8] Monash Univ, Sch Med & Hlth Sci, Selangor, Malaysia
[9] Ctr Natl Genotypage, Evry, France
来源：
TISSUE ANTIGENS | 2011年 / 77卷 / 02期
关键词：
TNF haplotype; immunogenetics; neuropathy; HIV; NRTI; inflammation; CLINICAL-FEATURES; HIV; RISK; RECONSTRUCTION; PREVALENCE; EXPRESSION; DEMENTIA; DISEASE;
D O I：
10.1111/j.1399-0039.2010.01570.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In human immunodeficiency virus (HIV) patients, neuropathy is a common adverse side effect to some antiretroviral treatments, particularly stavudine. As stavudine is cheap, it is widely used in Asia and Africa. We showed that increasing age and height moderately predict the development of neuropathy. This was improved by the inclusion of tumour necrosis factor (TNF)-1031 (rs1799964). To investigate this association, Malay (n = 64), Chinese (n = 74) and Caucasian patients (n = 37) exposed to stavudine were screened for neuropathy. DNA samples were genotyped for polymorphisms in the central major histocompatibility complex (MHC) near TNF, and haplotypes were derived. The haplotype group FVa6,7,8 (incorporating TNF-1031) was found to be associated with neuropathy in Chinese patients in bivariate analyses (P = 0.03), and in Malays and Chinese in a multivariate analysis correcting for age and height (P = 0.02, P = 0.03, respectively). This trend was also confirmed in Caucasians.
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页码：126 / 130
页数：5
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