RNAs: regulators of bacterial virulence

被引：158

作者：

Gripenland, Jonas ^{[1
,2
]}

Netterling, Sakura ^{[1
,2
]}

Loh, Edmund ^{[1
,2
]}

Tiensuu, Teresa ^{[1
,2
]}

Toledo-Arana, Alejandro ^{[3
]}

Johansson, Jorgen ^{[1
,2
]}

机构：

[1] Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden

[2] Umea Univ, Lab Mol Infect Med Sweden MIMS, S-90187 Umea, Sweden

[3] Univ Publ Navarra CSIC Gobierno Navarra, Inst Agrobiotecnol, Pamplona 31006, Spain

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 12期

基金：

西班牙国家研究理事会; 欧洲研究理事会; 瑞典研究理事会;

关键词：

STAPHYLOCOCCUS-AUREUS RNAIII; HFQ-BINDING RNAS; MESSENGER-RNA; ESCHERICHIA-COLI; LISTERIA-MONOCYTOGENES; VIBRIO-CHOLERAE; GENE-EXPRESSION; ANTISENSE RNA; PERVASIVE TRANSCRIPTION; CRYSTAL-STRUCTURE;

D O I：

10.1038/nrmicro2457

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5 and 3 untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.

引用

页码：857 / 866

页数：10

共 110 条

[1]

Anderson KL, 2009, INT J MICROBIOL

[2] The critical role of RNA processing and degradation in the control of gene expression [J].

Arraiano, Cecilia M. ;

Andrade, Jose M. ;

Domingues, Susana ;

Guinote, Ines B. ;

Malecki, Michal ;

Matos, Rute G. ;

Moreira, Ricardo N. ;

Pobre, Vania ;

Reis, Filipa P. ;

Saramago, Margarida ;

Silva, Ines J. ;

Viegas, Sandra C. .

FEMS MICROBIOLOGY REVIEWS, 2010, 34 (05) :883-923

[3] Cartography of Methicillin-Resistant S. aureus Transcripts: Detection, Orientation and Temporal Expression during Growth Phase and Stress Conditions [J].

Beaume, Marie ;

Hernandez, David ;

Farinelli, Laurent ;

Deluen, Cecile ;

Linder, Patrick ;

Gaspin, Christine ;

Romby, Pascale ;

Schrenzel, Jacques ;

Francois, Patrice .

PLOS ONE, 2010, 5 (05)

[4] Base pairing small RNAs and their roles in global regulatory networks [J].

Beisel, Chase L. ;

Storz, Gisela .

FEMS MICROBIOLOGY REVIEWS, 2010, 34 (05) :866-882

[5] All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay [J].

Belasco, Joel G. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2010, 11 (07) :467-478

[6] Pervasive transcription constitutes a new level of eukaryotic genome regulation [J].

Berretta, Julia ;

Morillon, Antonin .

EMBO REPORTS, 2009, 10 (09) :973-982

[7] Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism [J].

Boisset, Sandrine ;

Geissmann, Thomas ;

Huntzinger, Eric ;

Fechter, Pierre ;

Bendridi, Nadia ;

Possedko, Maria ;

Chevalier, Clement ;

Helfer, Anne Catherine ;

Benito, Yvonne ;

Jacquier, Alain ;

Gaspin, Christine ;

Vandenesch, Francois ;

Romby, Pascale .

GENES & DEVELOPMENT, 2007, 21 (11) :1353-1366

[8] The ribonucleases J1 and J2 are essential for growth and have independent roles in mRNA decay in Streptococcus pyogenes [J].

Bugrysheva, Julia V. ;

Scott, June R. .

MOLECULAR MICROBIOLOGY, 2010, 75 (03) :731-743

[9] The RNA degradosome of Escherichia coli:: An mRNA-degrading machine assembled on RNase E [J].

Carpousis, Agamemnon J. .

ANNUAL REVIEW OF MICROBIOLOGY, 2007, 61 :71-87

[10] A Staphylococcus aureus Small RNA Is Required for Bacterial Virulence and Regulates the Expression of an Immune-Evasion Molecule [J].

Chabelskaya, Svetlana ;

Gaillot, Olivier ;

Felden, Brice .

PLOS PATHOGENS, 2010, 6 (06)

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