Insights on immunological aging derived from the T lymphocyte cellular senescence model

被引：31
作者：
Effros, RB
机构：
[1] Dept. of Pathol. and Lab. Medicine, UCLA School of Medicine, Los Angeles, CA 90024-1732
来源：
EXPERIMENTAL GERONTOLOGY | 1996年 / 31卷 / 1-2期
关键词：
cellular senescence; immunosenescence; T cell senescence;
D O I：
10.1016/0531-5565(95)00017-8
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
A human T cell culture system has been developed to study cellular senescence in a manner analogous to that used for fibroblasts, Using this system, several markers of replicative senescence have been identified. Evidence is provided to show that new insights into the immune deficiency of aging as well as HIV infection have emerged from the in vitro model. The culture model is now being exploited to dissect the basic mechanisms underlying the senescence program in T cells.
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页码：21 / 27
页数：7
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