LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement

被引：11

作者：

Kyriakopoulos, Christos P. ^{[1
,2
,3
,4
]}

Kapelios, Chris J. ^{[1
,2
,3
]}

Stauder, Elizabeth L. ^{[1
,2
,3
,4
]}

Taleb, Iosif ^{[1
,2
,3
,4
]}

Hamouche, Rana ^{[4
]}

Sideris, Konstantinos ^{[1
,2
,3
]}

Koliopoulou, Antigone G. ^{[1
,2
,3
,5
,6
]}

Bonios, Michael J. ^{[1
,2
,3
,5
,6
]}

Drakos, Stavros G. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Utah Hlth, Div Cardiovasc Med, Salt Lake City, UT 84132 USA

[2] Univ Utah Hlth, Div Cardiothorac Surg, Salt Lake City, UT 84132 USA

[3] Sch Med, Salt Lake City, UT 84132 USA

[4] Univ Utah, Nora Eccles Harrison Cardiovasc Res & Training In, Salt Lake City, UT 84112 USA

[5] Onassis Cardiac Surg Ctr, Div Cardiol, Athens 17674, Greece

[6] Onassis Cardiac Surg Ctr, Div Cardiothorac Surg, Athens 17674, Greece

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 12期

关键词：

heart failure; mechanical circulatory support; left ventricular assist device; reverse remodeling; myocardial recovery; VENTRICULAR ASSIST DEVICE; DOBUTAMINE STRESS ECHOCARDIOGRAPHY; MECHANICAL CIRCULATORY SUPPORT; MYOCARDIAL RECOVERY; CONTINUOUS-FLOW; CARDIAC RECOVERY; DILATED CARDIOMYOPATHY; EXERCISE PERFORMANCE; CONTRACTILE RESERVE; EJECTION FRACTION;

D O I：

10.3390/jcm11123542

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac improvement, allowing LVAD support withdrawal in a subset of patients. In the first part of this review, we discuss the historical background, current evidence on the incidence and assessment of LVAD-mediated cardiac recovery, and out-comes including quality of life after LVAD support withdrawal. In the second part, we discuss current and future opportunities to promote LVAD-mediated reverse remodeling and improve our pathophysiological understanding of HF and recovery for the benefit of the greater HF population.

引用

页数：26

共 123 条

[1] Imaging, Biomarker, and Clinical Predictors of Cardiac Remodeling in Heart Failure With Reduced Ejection Fraction [J].

Aimo, Alberto ;

Gaggin, Hanna K. ;

Barison, Andrea ;

Emdin, Michele ;

Januzzi, James L., Jr. .

JACC-HEART FAILURE, 2019, 7 (09) :782-794

[2] Incomplete Recovery of Myocyte Contractile Function Despite Improvement of Myocardial Architecture With Left Ventricular Assist Device Support [J].

Ambardekar, Amrut V. ;

Walker, John S. ;

Walker, Lori A. ;

Cleveland, Joseph C., Jr. ;

Lowes, Brian D. ;

Buttrick, Peter M. .

CIRCULATION-HEART FAILURE, 2011, 4 (04) :425-+

[3] Hemodynamic Stress Echocardiography in Patients Supported With a Continuous-Flow Left Ventricular Assist Device [J].

Andersen, Mads ;

Gustafsson, Finn ;

Madsen, Per Lav ;

Brassard, Patrice ;

Jensen, Anette Schophuus ;

Secher, Niels ;

Hassager, Christian ;

Nordsborg, Nikolai ;

Moller, Jacob Eifer .

JACC-CARDIOVASCULAR IMAGING, 2010, 3 (08) :854-859

[4]

[Anonymous], JOURNAL OF THE AMERICAN

[5] Outcomes of patients after successful left ventricular assist device explantation: a EUROMACS study [J].

Antonides, Christiaan F. J. ;

Schoenrath, Felix ;

de By, Theo M. M. H. ;

Muslem, Rahatullah ;

Veen, Kevin ;

Yalcin, Yunus C. ;

Netuka, Ivan ;

Gummert, Jan ;

Potapov, Evgenij V. ;

Meyns, Bart ;

Ozbaran, Mustafa ;

Schibilsky, David ;

Caliskan, Kadir .

ESC HEART FAILURE, 2020, 7 (03) :1085-1094

[6] The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure [J].

Badolia, Rachit ;

Ramadurai, Dinesh K. A. ;

Abel, E. Dale ;

Ferrin, Peter ;

Taleb, Iosif ;

Shankar, Thirupura S. ;

Krokidi, Aspasia Thodou ;

Navankasattusas, Sutip ;

McKellar, Stephen H. ;

Yin, Michael ;

Kfoury, Abdallah G. ;

Wever-Pinzon, Omar ;

Fang, James C. ;

Selzman, Craig H. ;

Chaudhuri, Dipayan ;

Rutter, Jared ;

Drakos, Stavros G. .

CIRCULATION, 2020, 142 (03) :259-274

[7] Treatment of HF in an Era of Multiple Therapies Statement From the HF Collaboratory [J].

Bhatt, Ankeet S. ;

Abraham, William T. ;

Lindenfeld, Joann ;

Bristow, Michael ;

Carson, Peter E. ;

Felker, G. Michael ;

Fonarow, Gregg C. ;

Greene, Stephen J. ;

Psotka, Mitchell A. ;

Solomon, Scott D. ;

Stockbridge, Norman ;

Teerlink, John R. ;

Vaduganathan, Muthiah ;

Wittes, Janet ;

Fiuzat, Mona ;

O'Connor, Christopher M. ;

Butler, Javed .

JACC-HEART FAILURE, 2021, 9 (01) :1-12

[8]

Birks E., 2020, Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease, P223, DOI [10.1016/B978-0-323-56699-5.00019-X, DOI 10.1016/B978-0-323-56699-5.00019-X]

[9] Left ventricular assist device and drug therapy for the reversal of heart failure [J].

Birks, Emma J. ;

Tansley, Patrick D. ;

Hardy, James ;

George, Robert S. ;

Bowles, Christopher T. ;

Burke, Margaret ;

Banner, Nicholas R. ;

Khaghani, Asghar ;

Yacoub, Magdi H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (18) :1873-1884

[10] Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure]) Medium-Term and Primary End Point Results [J].

Birks, Emma J. ;

Drakos, Stavros G. ;

Patel, Snehal R. ;

Lowes, Brian D. ;

Selzman, Craig H. ;

Starling, Randall C. ;

Trivedi, Jaimin ;

Slaughter, Mark S. ;

Alturi, Pavin ;

Goldstein, Daniel ;

Maybaum, Simon ;

Um, John Y. ;

Margulies, Kenneth B. ;

Stehlik, Josef ;

Cunningham, Christopher ;

Farrar, David J. ;

Rame, Jesus E. .

CIRCULATION, 2020, 142 (21) :2016-2028

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