Copper(I)-catalyzed asymmetric intramolecular C-arylation with ureas as the additives: highly enantioselective formation of spirooxindoles

被引：2

作者：

Ma, Haowen ^{[1
]}

Feng, Jiajie ^{[2
,3
]}

Zhou, Wei ^{[1
]}

Chen, Chen ^{[1
]}

Deng, Zhuoji ^{[1
]}

Zhou, Fengtao ^{[1
]}

Ouyang, Yifan ^{[1
]}

Zhang, Xinhao ^{[2
,3
]}

Cai, Qian ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China

[2] Peking Univ Shenzhen Grad Sch, Lab Computat Chem & Drug Design, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China

[3] Shenzhen Bay Lab, Shenzhen 518132, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 34期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ALPHA-ARYLATION; COOPERATIVE CATALYSIS; PHOTOREDOX CATALYSIS; COUPLING REACTIONS; DUAL CATALYSIS; ARYL BROMIDES; EFFICIENT; ALKYLATION; ACTIVATION; AMINATION;

D O I：

10.1039/d1ob01327k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cooperative catalytic strategy is developed for a copper-catalyzed asymmetric intramolecular C-arylation reaction with ureas as the co-catalysts. By forming hydrogen bonds with 1,3-dicarbonyl structures, ureas can activate the substrates, stabilize the carbanion intermediates and the products, and fix the syn-configurations of 1,3-dicarbonyl structures. They help enhance the reactivity, prevent side reactions and improve the enantioselectivities.

引用

页码：7480 / 7484

页数：5

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