Simvastatin

被引：26

作者：

Cejka, J

Kratochvíl, B

Císarová, I

Jegorov, A

机构：

[1] IVAX Pharmaceut sro, Res Unit, Ceske Budejovice 370005, Czech Republic

[2] Prague Inst Chem Technol, Dept Solid State Chem, CR-16628 Prague 6, Czech Republic

[3] Charles Univ, Dept Inorgan Chem, Prague 12843 2, Czech Republic

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 2003年 / 59卷 / 08期

关键词：

Conformations - Crystal structure - Enzymes - Hydrogen bonds - Molecular structure - Synthesis (chemical);

D O I：

10.1107/S0108270103012514

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simvastatin, or (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl] ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, C25H38O5, is almost isostructural with lovastatin, and the general conformational features are closely related to those of other reported crystal structures of statins. The only hydrogen bond present facilitates the formation of infinite chains of molecules along the b axis.

引用

页码：O428 / O430

页数：3

共 14 条

[1] DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS-TERREUS [J].