Low 25-OH vitamin D levels at time of diagnosis and recurrence of ovarian cancer

被引:10
作者
Granato, Teresa [1 ]
Manganaro, Lucia [2 ]
Petri, Luca [3 ]
Porpora, Maria Grazia [4 ]
Viggiani, Valentina [3 ]
Angeloni, Antonio [3 ]
Anastasi, Emanuela [3 ]
机构
[1] CNR, IBPM, Viale Regina Elena 324, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Dept Radiol Oncol & Pathol Sci, Piazzale Aldo Moro 5, I-00185 Rome, Italy
[3] Univ Roma La Sapienza, Dept Mol Med, Piazzale Aldo Moro 5, I-00185 Rome, Italy
[4] Univ Roma La Sapienza, Dept Gynecol Obstet & Urol, Piazzale Aldo Moro 5, I-00185 Rome, Italy
关键词
25-OH vitamin D; Biomarker; Epithelial ovarian cancer; Follow-up; HE-4;
D O I
10.1007/s13277-015-4055-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The objective of this study was to evaluate the correlation between 25-OH vitamin D and ovarian cancer as a diagnostic marker or recurrence disease marker. We studied the following: (1) 61 women without gynecologic diseases, (2) 45 women affected by benign ovarian disease, (3) 46 women with recent diagnosis of ovarian cancer, (4) 26 follow-up women with recurrent ovarian cancer, and (5) 32 follow-up women with stable ovarian cancer. The 25-OH vitamin D was quantified with LUMIPULSEA (R) G 25-OH vitamin D on LUMIPULSEA (R) G 1200 (Fujirebio, Japan). As a threshold value, identified by ROC curve analysis, 20.2 ng/mL (sensitivity 73.3 %, specificity 84 %) was chosen corresponding to the limit between sufficient and insufficient 25-OH vitamin D according to the WHO. Low 25-OH vitamin D levels were observed in 26 % of women without gynecologic diseases, in 80 % of women with recent diagnosis of ovarian cancer and in 24 % women affected by benign ovarian diseases (p < 0.001). The follow-up study showed an insufficient level of 25-OH vitamin D in 73 % women with recurrent ovarian cancer and in 47 % women with stable ovarian cancer (p < 0.0003). This study showed that patients with ovarian cancer are often insufficient in 25-OH vitamin D compared to women with benign ovarian diseases. The women with recurrent ovarian cancer presented more often low levels compared to women with stable ovarian cancer. This study suggests that 25-OH vitamin D, due to its antiproliferative properties, can be a good marker for ovarian cancer also.
引用
收藏
页码:2177 / 2181
页数:5
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