Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures

被引：17

作者：

Lima, Daiana Correia ^{[1
]}

do Vale, Tiago Gurgel ^{[1
]}

Arganaraz, Gustavo Adolfo ^{[1
]}

Vasconcelos Varella, Pedro Paulo ^{[1
]}

Frussa-Filho, Roberto ^{[2
]}

Cavalheiro, Esper Abrao ^{[1
]}

Naffah-Mazzacoratti, Maria da Graca ^{[1
,3
]}

Amado, Debora ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Disciplina Neurol Expt, BR-04023900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Disciplina Farmacol, BR-04023900 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Bioquim, BR-04023900 Sao Paulo, Brazil

来源：

EPILEPSY & BEHAVIOR | 2010年 / 18卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

Pilocarpine epilepsy model; Pregnancy; Maternal seizures; Behavior; Motor coordination deficits; Hypoxia; PRENATAL STRESS; PILOCARPINE; ISCHEMIA; HYPOXIA; BRAIN; MODEL;

D O I：

10.1016/j.yebeh.2010.02.024

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We investigated the effects of exposure to maternal convulsive seizures in utero on the behavior of offspring. An epilepsy model was induced in female rats by administration of pilocarpine. Seizure frequency was evaluated for 60 days. The rats were then allowed to mate, and seizure frequency during pregnancy was recorded and compared with prepregnancy frequency. After birth, placentas of mothers were submitted for histopathological analysis. The behavior of the offspring was evaluated 3 months after birth. There was a decline in seizure frequency even though the placentas from epileptic mothers showed areas of ischemic infarction indicative of fetal hypoxia. Offspring of epileptic mothers manifested deficits in motor coordination in the rotarod test and increased immobility in the open-field test. No changes in anxiety and depression-like behaviors were observed. These results suggest that "in utero" exposure to maternal seizures can produce motor deficits in adult life, perhaps as a result of fetal hypoxia. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：45 / 49

页数：5

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