Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study

被引：15

作者：

Fuertes, Elaine ^{[1
,2
,3
,4
]}

Markevych, Iana ^{[5
,6
]}

Jarvis, Deborah ^{[4
,7
]}

Vienneau, Danielle ^{[8
,9
]}

de Hoogh, Kees ^{[8
,9
]}

Maria Anto, Josep ^{[1
,2
,3
]}

Bowatte, Gayan ^{[10
]}

Bono, Roberto ^{[11
]}

Corsico, Angelo G. ^{[12
,13
]}

Emtner, Margareta ^{[14
]}

Gislason, Thorarinn ^{[15
]}

Antonio Gullon, Jose ^{[16
]}

Heinrich, Joachim ^{[4
,5
]}

Henderson, John ^{[17
]}

Holm, Mathias ^{[18
]}

Johannessen, Ane ^{[19
,20
]}

Leynaert, Benedicte ^{[21
,22
]}

Marcon, Alessandro ^{[23
]}

Marchetti, Pierpaolo ^{[23
]}

Martinez Moratalla, Jesus ^{[24
,25
,26
]}

Pascual, Silvia ^{[27
]}

Probst-Hensch, Nicole ^{[8
,28
]}

Luis Sanchez-Ramos, Jose ^{[29
]}

Siroux, Valerie ^{[30
]}

Sommar, Johan ^{[31
]}

Weyler, Joost ^{[32
]}

Kuenzli, Nino ^{[8
,9
]}

Jacquemin, Benedicte ^{[1
,2
,3
,33
,34
]}

Garcia-Aymerich, Judith ^{[1
,2
,3
]}

机构：

[1] ISGlobal, Barcelona, Spain

[2] Univ Pompeu Fabra UPF, Barcelona, Spain

[3] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[4] Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England

[5] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Munich, Germany

[6] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany

[7] Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England

[8] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[9] Univ Basel, Basel, Switzerland

[10] Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia

[11] Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy

[12] IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy

[13] Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy

[14] Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden

[15] Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland

[16] Hosp San Agustin, Dept Pneumol, Aviles, Asturias, Spain

[17] Univ Bristol, Britsol Med Sch, Populat Hlth Sci, Bristol, Avon, England

[18] Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden

[19] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway

[20] Haukeland Hosp, Dept Occupat Med, Bergen, Norway

[21] INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France

[22] Univ Paris Diderot Paris, UMR 1152, Paris, France

[23] Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy

[24] Complejo Hosp Univ Albacete CHUA, Serv Neumol, Albacete, Spain

[25] Serv Salud Castilla La Mancha SESCAM, Castilla La Mancha, Spain

[26] Univ Castilla La Mancha, Fac Med Albacete, Albacete, Spain

[27] OSI Barrualde Galdakao, Galdakao Hosp, Resp Dept, Biscay, Spain

[28] Univ Basel, Dept Publ Hlth, Basel, Switzerland

[29] Univ Huelva, Dept Nursing, Huelva, Spain

[30] UGA, Inst Adv Biosci, Team Environm Epidemiol Appl Reprod & Resp Hlth, Inserm,U1209,CNRS,UMR 5309, Grenoble, France

[31] Umea Univ, Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umea, Sweden

[32] Univ Antwerp, Epidemiol & Social Med, Antwerp, Belgium

[33] Inst Med Sante & Rech Med, U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France

[34] Univ Versailles St Quentin En Yvelines, UMR S1168, Versailles, France

来源：

ENVIRONMENT INTERNATIONAL | 2018年 / 120卷

关键词：

Air pollution; Cohort; Lung function; Physical activity; Smoking; RESPIRATORY HEALTH SURVEY; USE REGRESSION-MODELS; FUNCTION DECLINE; PM2.5; ABSORBENCY; NO2; AREAS; EXPOSURE; INACTIVITY; STABILITY; PMCOARSE;

D O I：

10.1016/j.envint.2018.07.032

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas. Objective: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters < 2.5 mu m (PM2.5) and < 10 mu m (PM10) modify the effect of physical activity on lung function among never- (N = 2801) and current (N = 1719) smokers in the multi-center European Community Respiratory Health Survey. Methods: Associations between repeated assessments (at 27-57 and 39-67 years) of being physically active (physical activity: >= 2 times and >= 1 h per week) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated using adjusted mixed linear regression models. Models were conducted separately for never-and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations (<= 75th percentile (low/medium) versus > 75th percentile (high)). Results: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03). Conclusions: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear.

引用

页码：364 / 372

页数：9

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