Autophagy is an important cellular process by which ATG5 initiates the formation of double membrane vesicles (DMVs). Upon infection, DMVs have been shown to harbor the replicase complex of positive-strand RNA viruses such as MHV, poliovirus. and equine arteritis virus. Recently, it has been shown that autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection Here, we identified ATG5 as an interacting protein for the HCV NS5B ATG5/NS5B interaction was confirmed by co-IP and metabolic labeling studies. Furthermore. ATG5 protein colocalizes with NS4B, a constituent of the membranous web Importantly, immunofluorescence staining demonstrated a strong colocalization of ATG5 and NS5B within perinuclear regions of infected cells at 2 days postinfection However, colocalization was completely lacking at 5 DPI, suggesting that HCV utilizes ATG5 as a proviral factor during the onset of viral infection Finally, inhibition of autophagy through ATG5 silencing blocks HCV replication. (C) 2010 Elsevier Inc All rights reserved
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Ait-Goughoulte, Malika
Kanda, Tatsuo
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Kanda, Tatsuo
Meyer, Keith
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Meyer, Keith
Ryerse, Jan S.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Pathol, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Ryerse, Jan S.
Ray, Ratna B.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Pathol, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Ray, Ratna B.
Ray, Ranjit
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
St Louis Univ, Dept Mol Microbiol & Immunol, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
机构:
Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
Aligo, Jason
Jia, Shuaizheng
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Transfus Med, Beijing 100850, Peoples R ChinaPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
Jia, Shuaizheng
Manna, David
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
Manna, David
Konan, Kouacou V.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Gao, L
Aizaki, H
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Aizaki, H
He, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
He, JW
Lai, MMC
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Ait-Goughoulte, Malika
Kanda, Tatsuo
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Kanda, Tatsuo
Meyer, Keith
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Meyer, Keith
Ryerse, Jan S.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Pathol, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Ryerse, Jan S.
Ray, Ratna B.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Pathol, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
Ray, Ratna B.
Ray, Ranjit
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
St Louis Univ, Dept Mol Microbiol & Immunol, St Louis, MO 63103 USASt Louis Univ, Dept Internal Med, St Louis, MO 63103 USA
机构:
Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
Aligo, Jason
Jia, Shuaizheng
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Transfus Med, Beijing 100850, Peoples R ChinaPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
Jia, Shuaizheng
Manna, David
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
Manna, David
Konan, Kouacou V.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Althouse Lab 308, University Pk, PA 16802 USA
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Gao, L
Aizaki, H
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
Aizaki, H
He, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
He, JW
Lai, MMC
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USAUniv So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA