Different P105 promoter activities among natural variants of human papillomavirus type 18

被引：37

作者：

Sichero, L

Franco, EL

Villa, LL

机构：

[1] Ludwig Inst Canc Res, Dept Virol, BR-01509010 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Quim, Sao Paulo, Brazil

[3] McGill Univ, Dept Epidemiol, Montreal, PQ, Canada

[4] McGill Univ, Dept Oncol, Montreal, PQ, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 191卷 / 05期

关键词：

D O I：

10.1086/427825

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Association between non-European variants of human papillomavirus (HPV) type 16 (HPV-16) and HPV-18 and cervical lesions has been suggested. To compare the P105 promoter activity among 6 HPV-18 variants, their complete long control regions (LCRs), as well as that of HeLa cells, were cloned upstream of the luciferase gene and transiently transfected in C33 cells. Whereas the B18-2 European variant showed the lowest promoter activity, the Asian-Amerindian variant, B183, had the highest activity. All variants tested were more active than the P97 HPV-16 prototype promoter. Differences in the LCR that impact P105 promoter activity could be responsible for the observed variability in oncogenic potential.

引用

页码：739 / 742

页数：4

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