Variation in the proregion structure of heparin-binding EGF-like growth factor precursors

被引：1

作者：

Loukianov, EV ^{[1
]}

Loukianova, T ^{[1
]}

Wiedlocha, A ^{[1
]}

Olsnes, S ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Inst Canc Res, Dept Biochem, Oslo, Norway

来源：

GENE | 1998年 / 212卷 / 01期

关键词：

HB-EGF; growth factor precursor; splicing variants; proregion; heparin;

D O I：

10.1016/S0378-1119(98)00139-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In a previous study, we have isolated and characterized cDNA encoding a novel 'short form' of heparin-binding EGF-like growth factor (SF HB-EGF) (Loukianov et al., 1997). In the present work, we have found that cDNA for SF HB-EGF and for full-length HB-EGF are each represented by two variants, which we refer to as L and P forms. The L form is the previously known form of HB-EGF cDNA and encodes a leucine in position 33. The P form described in this report, encodes a proline in codon 33. The L33P substitution is predicted to cause a significant alteration in the proregion structure of SF HB-EGF and HB-EGF. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 4

页数：4

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