Variation in the proregion structure of heparin-binding EGF-like growth factor precursors

被引：1

作者：

Loukianov, EV ^{[1
]}

Loukianova, T ^{[1
]}

Wiedlocha, A ^{[1
]}

Olsnes, S ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Inst Canc Res, Dept Biochem, Oslo, Norway

来源：

GENE | 1998年 / 212卷 / 01期

关键词：

HB-EGF; growth factor precursor; splicing variants; proregion; heparin;

D O I：

10.1016/S0378-1119(98)00139-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In a previous study, we have isolated and characterized cDNA encoding a novel 'short form' of heparin-binding EGF-like growth factor (SF HB-EGF) (Loukianov et al., 1997). In the present work, we have found that cDNA for SF HB-EGF and for full-length HB-EGF are each represented by two variants, which we refer to as L and P forms. The L form is the previously known form of HB-EGF cDNA and encodes a leucine in position 33. The P form described in this report, encodes a proline in codon 33. The L33P substitution is predicted to cause a significant alteration in the proregion structure of SF HB-EGF and HB-EGF. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 4

页数：4

共 50 条

[21] Autocrine expression of the epidermal growth factor receptor ligand heparin-binding EGF-like growth factor in cervical cancer
Schrevel, Marlies
Osse, E. Michelle
Prins, Frans A.
Trimbos, J. Baptist M. Z.
Fleuren, Gert Jan
Gorter, Arko
Jordanova, Ekaterina S.
INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 50 (06) : 1947 - 1954
[22] Metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor and its pathophysiological roles
Higashiyama, S
PROTEIN AND PEPTIDE LETTERS, 2004, 11 (05) : 443 - 450
[23] Heparin-binding EGF-like growth factor expression and biological action in human pancreatic cancer cells
Yokoyama, M
Funatomi, H
Hope, C
Damm, D
Friess, H
Buchler, MW
Abraham, J
Korc, M
INTERNATIONAL JOURNAL OF ONCOLOGY, 1996, 8 (02) : 289 - 295
[24] Heparin-Binding EGF-Like Growth Factor Promotes Epithelial-Mesenchymal Transition in Human Keratinocytes
Stoll, Stefan W.
Rittie, Laure
Johnson, Jessica L.
Elder, James T.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 (09) : 2148 - 2157
[25] Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor
Stawowczyk, Marcin
Wellenstein, Max D.
Lee, Sharrell B.
Yomtoubian, Shira
Durrans, Anna
Choi, Hyejin
Narula, Navneet
Altorki, Nasser K.
Gao, Dingcheng
Mittal, Vivek
NEOPLASIA, 2017, 19 (02): : 55 - 64
[26] Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistance
Wang, F.
Liu, R.
Lee, S. W.
Sloss, C. M.
Couget, J.
Cusack, J. C.
ONCOGENE, 2007, 26 (14) : 2006 - 2016
[27] Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells
Ota, Ichiro
Higashiyama, Shigeki
Masui, Takashi
Yane, Katsunari
Hosoi, Hiroshi
Matsuura, Nariaki
ONCOLOGY REPORTS, 2013, 30 (04) : 1593 - 1600
[28] Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster
Wang, XH
Wang, HB
Matsumoto, H
Roy, SK
Das, SK
Paria, BC
DEVELOPMENT, 2002, 129 (17): : 4125 - 4134
[29] Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistance
F Wang
R Liu
S W Lee
C M Sloss
J Couget
J C Cusack
Oncogene, 2007, 26 : 2006 - 2016
[30] Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats
Feng, Jiexiong
Mehta, Veela B.
El-Assal, Osama N.
Wu, Dan
Besner, Gail E.
PEPTIDES, 2006, 27 (06) : 1589 - 1596

← 1 2 3 4 5 →