Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

被引：56

作者：

Bohrer, Andrea C. ^{[1
]}

Castro, Ehydel ^{[1
]}

Hu, Zhidong ^{[2
,3
]}

Queiroz, Artur T. L. ^{[4
]}

Tocheny, Claire E. ^{[1
]}

Assmann, Maike ^{[1
]}

Sakai, Shunsuke ^{[5
]}

Nelson, Christine ^{[5
]}

Baker, Paul J. ^{[1
]}

Ma, Hui ^{[2
,3
]}

Wang, Lin ^{[3
,6
]}

Zilu, Wen ^{[3
,6
]}

du Bruyn, Elsa ^{[7
]}

Riou, Catherine ^{[7
]}

Kauffman, Keith D. ^{[5
]}

Moore, Ian N. ^{[9
]}

Del Nonno, Franca ^{[10
]}

Petrone, Linda ^{[11
,12
]}

Goletti, Delia ^{[11
,12
]}

Martineau, Adrian R. ^{[13
]}

Lowe, David M. ^{[13
]}

Cronan, Mark R. ^{[14
,15
]}

Wilkinson, Robert J. ^{[7
,16
,17
]}

Barry, Clifton E., III ^{[7
,18
]}

Via, Laura E. ^{[8
,18
]}

Barber, Daniel L. ^{[5
]}

Klion, Amy D. ^{[19
]}

Andrade, Bruno B. ^{[4
]}

Song, Yanzheng ^{[3
,6
]}

Wong, Ka-Wing ^{[2
,3
]}

Mayer-Barber, Katrin D. ^{[1
]}

机构：

[1] NIAID, Inflammat & Innate Immun Unit, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Sci Res, Shanghai, Peoples R China

[3] Fudan Univ, TB Ctr, Shanghai Emerging & Reemerging Infect Dis Inst, Shanghai, Peoples R China

[4] Fundacao Oswaldo Cruz, KAB Grp, Inst Goncalo Moniz, Multinatl Org Network Sponsoring Translat & Epide, Salvador, BA, Brazil

[5] NIAID, T Lymphocyte Biol Sect, Lab Parasit Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[6] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Thorac Surg, Shanghai, Peoples R China

[7] Univ Cape Town, Wellcome Ctr Infect Dis Res Africa, Inst Infect Dis & Mol Med, Rondebosch, South Africa

[8] NIAID, TB Imaging Program, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[9] NIAID, Infect Dis Pathogenesis Sect, Comparat Med Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[10] Ist Ricovero & Cura Carattere Sci, Pathol Unit, Natl Inst Infect Dis L Spallanzani, Rome, Italy

[11] Ist Ricovero & Cura Carattere Sci, Translat Res Unit, Dept Epidemiol, Rome, Italy

[12] Ist Ricovero & Cura Carattere Sci, Translat Res Unit, Preclin Res Natl Inst Infect Dis, Rome, Italy

[13] UCL, Inst Immun & Transplantat, London, England

[14] Max Planck Inst Infect Biol, In Vivo Cell Biol Infect Unit, Berlin, Germany

[15] Duke Univ, Dept Mol Genet & Microbiol, Sch Med, Durham, NC USA

[16] Imperial Coll London, Dept Infect Dis, London, England

[17] Francis Crick Inst, London, England

[18] NIAID, TB Res Sect, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[19] NIAID, Human Eosinophil Sect, Lab Parasit Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 218卷 / 10期

基金：

中国国家自然科学基金; 英国惠康基金; 英国科研创新办公室; 美国国家卫生研究院;

关键词：

MYCOBACTERIUM-MARINUM INFECTION; INTERFERON-GAMMA; IMMUNE-RESPONSE; RNA-SEQ; HEALTH; PATHOGENESIS; COINFECTION; DEFICIENT; DEFENSE; PACKAGE;

D O I：

10.1084/jem.20210469

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.

引用

页数：20

共 72 条

[1] Asymptomatic Helminth Infection in Active Tuberculosis Is Associated with Increased Regulatory and Th-2 Responses and a Lower Sputum Smear Positivity [J].