Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy

被引：89

作者：

Soderpalm, Ann-Charlott ^{[1
]}

Magnusson, Per ^{[2
]}

Ahlander, Anne-Christine ^{[3
]}

Karlsson, Jon ^{[1
]}

Kroksmark, Anna-Karin ^{[3
]}

Tulinius, Mar ^{[3
]}

Swolin-Eide, Diana ^{[3
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Univ Hosp Ostra, Inst Clin Sci,Dept Orthopaed, SE-41685 Gothenburg, Sweden

[2] Fac Hlth Sci, Dept Biomed & Surg, Div Clin Chem, Bone & Mineral Metab Unit, Linkoping, Sweden

[3] Univ Gothenburg, Sahlgrenska Acad, Queen Silvia Children Hosp, Dept Paediat,Inst Clin Sci, SE-41685 Gothenburg, Sweden

来源：

NEUROMUSCULAR DISORDERS | 2007年 / 17卷 / 11-12期

关键词：

children; skeleton; steroids; DXA; bone markers; calciotropic hormones;

D O I：

10.1016/j.nmd.2007.05.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This cross-sectional study examined bone mineral density, bone turnover, body composition and calciotropic hormones in 24 boys with Duchenne muscular dystrophy (DMD) (2.3-19.7 years), most of whom were being treated with prednisolone, and 24 age-matched healthy boys. Our study demonstrated lower bone mineral density in the DMD group for total body, spine, hip, heel and forearm measurements. These differences between DMD patients and controls increased with increasing age. Biochemical markers of both bone formation and resorption revealed reduced bone turnover in DMD patients. The fracture rate was not higher in DMD patients. The DMD group had low vitamin D levels but high leptin levels in comparison with the control group. Muscle strength correlated with bone mineral density assessed at the hip and heel in the DMD group. Interventions that increase bone formation should be considered, as DMD patients have reduced bone turnover in addition to their low bone mineral density. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：919 / 928

页数：10

共 59 条

[51] The novel bone alkaline phosphatase B1x isoform in children with kidney disease [J].