MicroRNA-183 family conservation and ciliated neurosensory organ expression

被引：127
作者：
Pierce, Marsha L. [1 ]
Weston, Michael D. [1 ]
Fritzsch, Bernd [1 ]
Gabel, Harrison W. [2 ,3 ]
Ruvkun, Gary [2 ,3 ]
Soukup, Garrett A. [1 ]
机构：
[1] Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
来源：
EVOLUTION & DEVELOPMENT | 2008年 / 10卷 / 01期
关键词：
D O I：
10.1111/j.1525-142X.2007.00217.x
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
MicroRNAs (miRNAs) are an integral component of the metazoan genome and affect posttranscriptional repression of target messenger RNAs. The extreme phylogenetic conservation of certain miRNAs suggests their ancient origin and crucial function in conserved developmental processes. We demonstrate that highly conserved miRNA-183 orthologs exist in both deuterostomes and protostomes and their expression is predominant in ciliated ectodermal cells and organs. The miRNA-183 family members are expressed in vertebrate sensory hair cells, in innervated regions of invertebrate deuterostomes, and in sensilla of Drosophila and C. elegans. Thus, miRNA-183 family member expression is conserved in possibly homologous but morphologically distinct sensory cells and organs. The results suggest that miR-183 family members contribute specifically to neurosensory development or function, and that extant metazoan sensory organs are derived from cells that share genetic programs of common evolutionary origin.
引用
收藏
页码：106 / 113
页数：8
相关论文
共 58 条
  • [41] Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lim, LP
    Lau, NC
    Garrett-Engele, P
    Grimson, A
    Schelter, JM
    Castle, J
    Bartel, DP
    Linsley, PS
    Johnson, JM
    [J]. NATURE, 2005, 433 (7027) : 769 - 773
  • [42] Anteroposterior patterning in hemichordates and the origins of the chordate nervous system
    Lowe, CJ
    Wu, M
    Salic, A
    Evans, L
    Lander, E
    Stange-Thomann, N
    Gruber, CE
    Gerhart, J
    Kirschner, M
    [J]. CELL, 2003, 113 (07) : 853 - 865
  • [43] Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
    Matei, V
    Pauley, S
    Kaing, S
    Rowitch, D
    Beisel, KW
    Morris, K
    Feng, F
    Jones, K
    Lee, J
    Fritzsch, B
    [J]. DEVELOPMENTAL DYNAMICS, 2005, 234 (03) : 633 - 650
  • [44] A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA50, maps to chromosome 7q32 between the DFNB17 and DFNB13 deafness loci -: art. no. e14
    Modamio-Hoybjor, S
    Moreno-Pelayo, MA
    Mencía, A
    del Castillo, I
    Chardenoux, S
    Morais, D
    Lathrop, M
    Petit, C
    Moreno, F
    [J]. JOURNAL OF MEDICAL GENETICS, 2004, 41 (02)
  • [45] Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear
    Pauley, Sarah
    Lai, Eseng
    Fritzsch, Bernd
    [J]. DEVELOPMENTAL DYNAMICS, 2006, 235 (09) : 2470 - 2482
  • [46] Pfeffer PL, 1998, DEVELOPMENT, V125, P3063
  • [47] Evidence for a microRNA expansion in the bilaterian ancestor
    Prochnik, Simon E.
    Rokhsar, Daniel S.
    Aboobaker, A. Aziz
    [J]. DEVELOPMENT GENES AND EVOLUTION, 2007, 217 (01) : 73 - 77
  • [48] The phylogenetic distribution of metazoan microRNAs: Insights into evolutionary complexity and constraint
    Sempere, Lorenzo F.
    Cole, Charles N.
    McPeek, Mark A.
    Peterson, Kevin J.
    [J]. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, 2006, 306B (06) : 575 - 588
  • [49] Research article -: The genome of the sea urchin Strongylocentrotus purpuratus
    Sodergren, Erica
    Weinstock, George M.
    Davidson, Eric H.
    Cameron, R. Andrew
    Gibbs, Richard A.
    Weinstock, George M.
    Angerer, Robert C.
    Angerer, Lynne M.
    Arnone, Maria Ina
    Burgess, David R.
    Burke, Robert D.
    Cameron, R. Andrew
    Coffman, James A.
    Davidson, Eric H.
    Dean, Michael
    Elphick, Maurice R.
    Ettensohn, Charles A.
    Foltz, Kathy R.
    Hamdoun, Amro
    Hynes, Richard O.
    Klein, William H.
    Marzluff, William
    McClay, David R.
    Morris, Robert L.
    Mushegian, Arcady
    Rast, Jonathan P.
    Sodergren, Erica
    Smith, L. Courtney
    Thorndyke, Michael C.
    Vacquier, Victor D.
    Weinstock, George M.
    Wessel, Gary M.
    Wray, Greg
    Zhang, Lan
    Sodergren, Erica
    Weinstock, George M.
    Angerer, Robert C.
    Angerer, Lynne M.
    Cameron, R. Andrew
    Davidson, Eric H.
    Elsik, Christine G.
    Ermolaeva, Olga
    Hlavina, Wratko
    Hofmann, Gretchen
    Kitts, Paul
    Landrum, Melissa J.
    Mackey, Aaron J.
    Maglott, Donna
    Panopoulou, Georgia
    Poustka, Albert J.
    [J]. SCIENCE, 2006, 314 (5801) : 941 - 952
  • [50] THE ORGANIZATION OF THE CHEMOSENSORY SYSTEM IN DROSOPHILA-MELANOGASTER - A REVIEW
    STOCKER, RF
    [J]. CELL AND TISSUE RESEARCH, 1994, 275 (01) : 3 - 26
123456