Organoids to study immune functions, immunological diseases and immunotherapy

被引：38

作者：

Ye, Wenrui ^{[1
,2
]}

Luo, Cong ^{[2
,3
]}

Li, Chenglong ^{[1
,2
]}

Huang, Jing ^{[4
,5
]}

Liu, Fangkun ^{[1
]}

机构：

[1] CSU, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Cent South Univ, Clin Med Eight Year Program, Xiangya Med Sch, Changsha, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China

[5] Cent South Univ, Mental Hlth Inst,Hunan Key Lab Psychiat & Mental, Xiangya Hosp 2,Chinese Natl Technol Inst Mental D, Chinese Natl Clin Res Ctr Mental Disorders Xiangy, Changsha 410011, Hunan, Peoples R China

来源：

CANCER LETTERS | 2020年 / 477卷

基金：

中国国家自然科学基金;

关键词：

Organoids; Immunity; Immune organoids; Immunological disease; Immunotherapy; IN-VITRO EXPANSION; T-CELL DEVELOPMENT; PROGENITOR CELLS; STEM-CELLS; HEMATOPOIETIC STEM; MALT1; PROTEASE; BONE-MARROW; CANCER; MODEL; GENERATION;

D O I：

10.1016/j.canlet.2020.02.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three-dimensional organoid culture systems show great promise as innovative physiological and pathophysiological models. Their applications in immunological research have been widely explored. For instance, immune organoids allow functional studies of immune system-related conditions, in a context that closely mimics the in vivo microenvironment, enabling an in-depth understanding of the immune tissue structures and functions. The newly developed coculture organoid and the air-liquid interface (ALI) systems also provided new insights for studying epithelia-immune cell interactions based on their endogenous distribution. Additionally, organoids have enabled the innovation of immunological disease models and exploration of the link between immunity and cancer, showing potential for personalized immunotherapy. This review is an overview of recent advances in the application of organoids in immunological research. Furthermore, the potential improvements for further utilization of organoids in personalized immunotherapy are discussed.

引用

页码：31 / 40

页数：10

共 119 条

[31] In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
Bartfeld, Sina
Bayram, Tulay
van de Wetering, Marc
Huch, Meritxell
Begthel, Harry
Kujala, Pekka
Vries, Robert
Peters, Peter J.
Clevers, Hans
[J]. GASTROENTEROLOGY, 2015, 148 (01) : 126 - U554
[32] A Missing Link in Genotype-Directed Cancer Therapy
Bernards, Rene
[J]. CELL, 2012, 151 (03) : 465 - 468
[33] Mouse models of cancer
Berns, Anton
Barbacid, Mariano
[J]. MOLECULAR ONCOLOGY, 2013, 7 (02) : 143 - 145
[34] Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Boj, Sylvia F.
Hwang, Chang-Il
Baker, Lindsey A.
Chio, Iok In Christine
Engle, Dannielle D.
Corbo, Vincenzo
Jager, Myrthe
Ponz-Sarvise, Mariano
Tiriac, Herve
Spector, Mona S.
Gracanin, Ana
Oni, Tobiloba
Yu, Kenneth H.
van Boxtel, Ruben
Huch, Meritxell
Rivera, Keith D.
Wilson, John P.
Feigin, Michael E.
Oehlund, Daniel
Handly-Santana, Abram
Ardito-Abraham, Christine M.
Ludwig, Michael
Elyada, Ela
Alagesan, Brinda
Biffi, Giulia
Yordanov, Georgi N.
Delcuze, Bethany
Creighton, Brianna
Wright, Kevin
Park, Youngkyu
Morsink, Folkert H. M.
Molenaar, I. Quintus
Rinkes, Inne H. Borel
Cuppen, Edwin
Hao, Yuan
Jin, Ying
Nijman, Isaac J.
Iacobuzio-Donahue, Christine
Leach, Steven D.
Pappin, Darryl J.
Hammell, Molly
Klimstra, David S.
Basturk, Olca
Hruban, Ralph H.
Offerhaus, George Johan
Vries, Robert G. J.
Clevers, Hans
Tuveson, David A.
[J]. CELL, 2015, 160 (1-2) : 324 - 338
[35] Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
Caganova, Marieta
Carrisi, Chiara
Varano, Gabriele
Mainoldi, Federica
Zanardi, Federica
Germain, Pierre-Luc
George, Laura
Alberghini, Federica
Ferrarini, Luca
Talukder, Asoke K.
Ponzoni, Maurilio
Testa, Giuseppe
Nojima, Takuya
Doglioni, Claudio
Kitamura, Daisuke
Toellner, Kai-M.
Su, I-hsin
Casola, Stefano
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (12) : 5009 - 5022
[36] CAMPANA D, 1985, J IMMUNOL, V134, P1524
[37] Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
Cayrol, Florencia
Diaz Flaque, Maria Celeste
Fernando, Tharu
Yang, Shao Ning
Andrea Sterle, Helena
Bolontrade, Marcela
Amoros, Mariana
Isse, Blanca
Norberto Farias, Ricardo
Ahn, Haelee
Tian, Ye F.
Tabbo, Fabrizio
Singh, Ankur
Inghirami, Giorgio
Cerchietti, Leandro
Alicia Cremaschi, Graciela
[J]. BLOOD, 2015, 125 (05) : 841 - 851
[38] BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy
Cerchietti, Leandro C.
Hatzi, Katerina
Caldas-Lopes, Eloisi
Yang, Shao Ning
Figueroa, Maria E.
Morin, Ryan D.
Hirst, Martin
Mendez, Lourdes
Shaknovich, Rita
Cole, Philip A.
Bhalla, Kapil
Gascoyne, Randy D.
Marra, Marco
Chiosis, Gabriela
Melnick, Ari
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (12) : 4569 - 4582
[39] Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Chen, Bi-Chang
Legant, Wesley R.
Wang, Kai
Shao, Lin
Milkie, Daniel E.
Davidson, Michael W.
Janetopoulos, Chris
Wu, Xufeng S.
Hammer, John A., III
Liu, Zhe
English, Brian P.
Mimori-Kiyosue, Yuko
Romero, Daniel P.
Ritter, Alex T.
Lippincott-Schwartz, Jennifer
Fritz-Laylin, Lillian
Mullins, R. Dyche
Mitchell, Diana M.
Bembenek, Joshua N.
Reymann, Anne-Cecile
Boehme, Ralph
Grill, Stephan W.
Wang, Jennifer T.
Seydoux, Geraldine
Tulu, U. Serdar
Kiehart, Daniel P.
Betzig, Eric
[J]. SCIENCE, 2014, 346 (6208) : 439 - +
[40] Elements of cancer immunity and the cancer-immune set point
Chen, Daniel S.
Mellman, Ira
[J]. NATURE, 2017, 541 (7637) : 321 - 330

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