Organoids to study immune functions, immunological diseases and immunotherapy

被引：38
作者：
Ye, Wenrui [1 ,2 ]
Luo, Cong [2 ,3 ]
Li, Chenglong [1 ,2 ]
Huang, Jing [4 ,5 ]
Liu, Fangkun [1 ]
机构：
[1] CSU, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
[2] Cent South Univ, Clin Med Eight Year Program, Xiangya Med Sch, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
[5] Cent South Univ, Mental Hlth Inst,Hunan Key Lab Psychiat & Mental, Xiangya Hosp 2,Chinese Natl Technol Inst Mental D, Chinese Natl Clin Res Ctr Mental Disorders Xiangy, Changsha 410011, Hunan, Peoples R China
来源：
CANCER LETTERS | 2020年 / 477卷
基金：
中国国家自然科学基金;
关键词：
Organoids; Immunity; Immune organoids; Immunological disease; Immunotherapy; IN-VITRO EXPANSION; T-CELL DEVELOPMENT; PROGENITOR CELLS; STEM-CELLS; HEMATOPOIETIC STEM; MALT1; PROTEASE; BONE-MARROW; CANCER; MODEL; GENERATION;
D O I：
10.1016/j.canlet.2020.02.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Three-dimensional organoid culture systems show great promise as innovative physiological and pathophysiological models. Their applications in immunological research have been widely explored. For instance, immune organoids allow functional studies of immune system-related conditions, in a context that closely mimics the in vivo microenvironment, enabling an in-depth understanding of the immune tissue structures and functions. The newly developed coculture organoid and the air-liquid interface (ALI) systems also provided new insights for studying epithelia-immune cell interactions based on their endogenous distribution. Additionally, organoids have enabled the innovation of immunological disease models and exploration of the link between immunity and cancer, showing potential for personalized immunotherapy. This review is an overview of recent advances in the application of organoids in immunological research. Furthermore, the potential improvements for further utilization of organoids in personalized immunotherapy are discussed.
引用
收藏
页码：31 / 40
页数：10
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