Intimal Sarcoma of the Pulmonary Artery Treated with Pazopanib

被引：17

作者：

Funatsu, Yohei ^{[1
]}

Hirayama, Miwa ^{[1
]}

Shiraishi, Junichi ^{[2
]}

Asakura, Takanori ^{[1
]}

Wakaki, Misa ^{[1
]}

Yamada, Erina ^{[1
]}

Fujimoto, Kazuyuki ^{[1
]}

Satomi, Ryosuke ^{[1
]}

Inaki, Shunsuke ^{[1
]}

Murata, Yuya ^{[2
]}

Oyamada, Yoshitaka ^{[1
]}

机构：

[1] Tokyo Med Ctr, Natl Hosp Org, Resp Med, Tokyo, Japan

[2] Tokyo Med Ctr, Natl Hosp Org, Pathol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 16期

关键词：

intimal sarcoma of the pulmonary artery; pazopanib; disease flare; tyrosine kinase inhibitor; ACQUIRED-RESISTANCE; DISEASE FLARE; LUNG-CANCER; TUMORS; DISCONTINUATION; THERAPY; TRIAL;

D O I：

10.2169/internalmedicine.55.6199

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intimal sarcoma is a rare disease with a poor prognosis. We herein report the case of a 71-year-old man with intimal sarcoma of the pulmonary artery treated with pazopanib. The tumor showed regression after 1 month of treatment. Hand-foot syndrome led to cessation of pazopanib, which triggered a disease flare. Pazopanib should be considered in patients with intimal sarcoma of the pulmonary artery that is unresectable or recurrent after surgery or cytotoxic chemotherapy. We must be careful about drug cessation, as it can lead to a disease flare.

引用

页码：2197 / 2202

页数：6

共 12 条

[1] Management of Primary Pulmonary Artery Sarcomas [J].

Blackmon, Shanda H. ;

Rice, David C. ;

Correa, Arlene M. ;

Mehran, Reza ;

Putnam, Joe B. ;

Smythe, W. Roy ;

Walkes, Jon-Cecil ;

Walsh, Garrett L. ;

Moran, Cesar ;

Singh, Harsh ;

Vaporciyan, Ara A. ;

Reardon, Michael .

ANNALS OF THORACIC SURGERY, 2009, 87 (03) :977-984

[2] Disease Flare after Tyrosine Kinase Inhibitor Discontinuation in Patients with EGFR-Mutant Lung Cancer and Acquired Resistance to Erlotinib or Gefitinib: Implications for Clinical Trial Design [J].

Chaft, Jamie E. ;

Oxnard, Geoffrey R. ;

Sima, Camelia S. ;

Kris, Mark G. ;

Miller, Vincent A. ;

Riely, Gregory J. .

CLINICAL CANCER RESEARCH, 2011, 17 (19) :6298-6303

[3] A Case Report of Chemo-sensitive Intimal Pulmonary Artery Sarcoma [J].

Chen, Xiaoxia ;

Ren, Shengxiang ;

Li, Aiwu ;

Zhou, Caicun .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 68 (01) :153-157

[4] ANTI-ANGIOGENESIS - NEW CONCEPT FOR THERAPY OF SOLID TUMORS [J].

FOLKMAN, J .

ANNALS OF SURGERY, 1972, 175 (03) :409-&

[5] LONG-TERM PALLIATION OF PULMONARY-ARTERY SARCOMA BY RADICAL EXCISION AND ADJUVANT THERAPY [J].

HEAD, HD ;

FLAM, MS ;

JOHN, MJ ;

LIPNIK, SS ;

SLATER, DL ;

STEWART, RD .

ANNALS OF THORACIC SURGERY, 1992, 53 (02) :332-334

[6] Should Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Be Continued beyond Progressive Disease? [J].

Kim, Young Hak ;

Fukuhara, Akiko ;

Mishima, Michiaki .

CASE REPORTS IN ONCOLOGY, 2011, 4 (03) :470-474

[7] Primary aortic intimal sarcoma of the endothelial cell type with long-term survival [J].

Majeski, J ;

Crawford, ES ;

Majeski, EI ;

Duttenhaver, JR .

JOURNAL OF VASCULAR SURGERY, 1998, 27 (03) :555-558

[8] Disease Flare After Treatment Discontinuation in a Patient With EML4-ALK Lung Cancer and Acquired Resistance to Crizotinib [J].

Pop, Oana ;

Pirvu, Augustin ;

Toffart, Anne-Claire ;

Moro-Sibilot, Denis .

JOURNAL OF THORACIC ONCOLOGY, 2012, 7 (08) :E1-E2

[9] A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies [J].

Ranieri, G. ;

Gadaleta, C. D. ;

Patruno, R. ;

Zizzo, N. ;

Daidone, M. G. ;

Hansson, M. G. ;

Paradiso, A. ;

Ribatti, D. .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2013, 88 (01) :187-197

[10] Tyrosine kinase inhibitors (TKIs) in human and pet tumours with special reference to breast cancer: A comparative review [J].

Ranieri, Girolamo ;

Pantaleo, Marianna ;

Piccinno, Mariagrazia ;

Roncetti, Maria ;

Mutinati, Maddalena ;

Marech, Ilaria ;

Patruno, Rosa ;

Rizzo, Annalisa ;

Sciorsci, Raffaele Luigi .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2013, 88 (02) :293-308

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