No evidence for linkage of chromosome 6p markers to schizophrenia in Southern African Bantu-speaking families

被引：25

作者：

Riley, BP

Rajagopalan, S

MogudiCarter, M

Jenkins, T

Williamson, R

机构：

[1] BARAGWANATH HOSP,DEPT PSYCHIAT,SOWETO,SOUTH AFRICA

[2] UNIV WITWATERSRAND,SOUTH AFRICAN INST MED RES,SCH PATHOL,DEPT GENET,JOHANNESBURG,SOUTH AFRICA

[3] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOL GENET,LONDON W2 1PG,ENGLAND

来源：

PSYCHIATRIC GENETICS | 1996年 / 6卷 / 02期

关键词：

homogeneity; linkage analysis; parametric; psychosis; South African;

D O I：

10.1097/00041444-199622000-00003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previous studies have yielded evidence for a locus conferring susceptibility to schizophrenia and schizophrenia spectrum disorders on chromosome 6p24-22 in a sample of multiply affected Irish families. We tested for linkage between highly polymorphic chromosome 6p24-22 markers and narrowly defined schizophrenia in a sample of 19 Southern African Bantu-speaking families, a population known to have diverged in the last 2000 years. There is no evidence to support the linkage of markers in this region of chromosome 6 to schizophrenia in this population.

引用

页码：41 / 49

页数：9

共 25 条

[1]

[Anonymous], 1982, SCHIZOPHRENIA EPIGEN

[2]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[3]

ANTONARAKIS SE, 1995, NAT GENET, V11, P235, DOI 10.1038/ng1195-235

[4] THE WEIGHTED RANK PAIRWISE CORRELATION STATISTIC FOR LINKAGE ANALYSIS - SIMULATION STUDY AND APPLICATION TO ALZHEIMERS-DISEASE [J].

COMMENGES, D ;

OLSON, J ;

WIJSMAN, E .

GENETIC EPIDEMIOLOGY, 1994, 11 (02) :201-212

[5]

COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252

[6]

Diehl S. R., 1994, American Journal of Human Genetics, V55, pA151

[7] GENDER AND SCHIZOPHRENIA - AGE AT ONSET AND SOCIODEMOGRAPHIC ATTRIBUTES [J].

GUREJE, O .

ACTA PSYCHIATRICA SCANDINAVICA, 1991, 83 (05) :402-405

[8] SCHIZOPHRENIA SUSCEPTIBILITY AND CHROMOSOME 6P24-22 [J].

GURLING, H ;

KALSI, G ;

CHEN, AHS ;

GREEN, M ;

BUTLER, R ;

READ, T ;

MURPHY, P ;

CURTIS, D ;

SHARMA, T ;

PETURSSON, H ;

BRYNJOLFSSON, T .

NATURE GENETICS, 1995, 11 (03) :234-235

[9] THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].

GYAPAY, G ;

MORISSETTE, J ;

VIGNAL, A ;

DIB, C ;

FIZAMES, C ;

MILLASSEAU, P ;

MARC, S ;

BERNARDI, G ;

LATHROP, M ;

WEISSENBACH, J .

NATURE GENETICS, 1994, 7 (02) :246-339

[10]

LATHROP GM, 1984, AM J HUM GENET, V36, P460

← 1 2 3 →