Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis

被引：8

作者：

Åkesson, E ^{[8
]}

Coraddu, F

Marrosu, MG

Massacesi, L

Hensiek, A

Harbo, HF

Oturai, A

Trojano, M

Momigliano-Richiardi, P

Cocco, E

Murru, R

Hilbert, J

Compston, A

Sawcer, S

机构：

[1] Univ Piemonte Orientale, Interdisciplinary Res Ctr Autoimmune Dis, Novara, Italy

[2] Univ Piemonte Orientale, Dipartimento Sci Med, Novara, Italy

[3] Univ Bari, Dipartimento Sci Neurol & Psichiatr, Bari, Italy

[4] Univ Copenhagen Hosp, Rigshosp, Dept Neurol, DK-2100 Copenhagen, Denmark

[5] Univ Hosp, Rikshosp, Inst Immunol, Oslo, Norway

[6] Univ Florence, Dipartimento Sci Neurol Psichiatr, Florence, Italy

[7] Univ Cagliari, Ctr Diagn & Cura Sclerosi Multipla, Sardinia, Italy

[8] Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, Stockholm, Sweden

[9] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

关键词：

multiple sclerosis; linkage; susceptibility gene; map density;

D O I：

10.1016/j.jneuroim.2003.08.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by these studies encompass around 60 cM of the chromosome. In order to explore this region further, we typed 13 microsatellite markers in the same 449 families originally studied in the individual screens. This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：31 / 38

页数：8

共 29 条

[1] A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis [J].

Akesson, E ;

Oturai, A ;

Berg, J ;

Fredrikson, S ;

Andersen, O ;

Harbo, HF ;

Laaksonen, M ;

Myhr, KM ;

Nyland, HI ;

Ryder, LP ;

Sandberg-Wollheim, M ;

Sorensen, PS ;

Spurkland, A ;

Svejgaard, A ;

Holmans, P ;

Compston, A ;

Hillert, J ;

Sawcer, S .

GENES AND IMMUNITY, 2002, 3 (05) :279-285

[2] Genomewide scans of complex human diseases:: True linkage is hard to find [J].

Altmüller, J ;

Palmer, LJ ;

Fischer, G ;

Scherb, H ;

Wjst, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (05) :936-950

[3] A genome screen for multiple sclerosis in Italian families [J].

Broadley, S ;

Sawcer, S ;

D'Alfonso, S ;

Hensiek, A ;

Coraddu, F ;

Gray, J ;

Roxburgh, R ;

Clayton, D ;

Buttinelli, C ;

Quattrone, A ;

Trojano, M ;

Massacesi, L ;

Compston, A .

GENES AND IMMUNITY, 2001, 2 (04) :205-210

[4] Comprehensive human genetic maps: Individual and sex-specific variation in recombination [J].

Broman, KW ;

Murray, JC ;

Sheffield, VC ;

White, RL ;

Weber, JL .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (03) :861-869

[5] International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16 [J].

Cavanaugh, J .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (05) :1165-1171

[6] A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission [J].

Clayton, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) :1170-1177

[7] A metric map of humans: 23,500 loci in 850 bands [J].

Collins, A ;

Frezal, J ;

Teague, J ;

Morton, NE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14771-14775

[8] Genetic analysis of multiple sclerosis. [J].

Compston A. ;

Sawcer S. .

Current Neurology and Neuroscience Reports, 2002, 2 (3) :259-266

[9] A genome screen for multiple sclerosis in Sardinian multiplex families [J].

Coraddu, F ;

Sawcer, S ;

D'Alfonso, S ;

Lai, M ;

Hensiek, A ;

Solla, E ;

Broadley, S ;

Mancosu, C ;

Pugliatti, M ;

Marrosu, MG ;

Compston, A .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (08) :621-626

[10] Linkage analysis of multiple sclerosis with candidate region markers in Sardinian and Continental Italian families [J].

D'Alfonso, S ;

Nisticò, L ;

Zavattari, P ;

Marrosu, MG ;

Murru, R ;

Lai, M ;

Massacesi, L ;

Ballerini, C ;

Gestri, D ;

Salvetti, M ;

Ristori, G ;

Bomprezzi, R ;

Trojanò, M ;

Liguori, M ;

Gambi, D ;

Quattrone, A ;

Fruci, D ;

Cucca, F ;

Richiardi, PM ;

Tosi, R .

EUROPEAN JOURNAL OF HUMAN GENETICS, 1999, 7 (03) :377-385

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