Effect of (-)-stepholidine on serum prolactin level of female rats

被引：0
|
作者：
Zou, LL [1 ]
Chen, Y [1 ]
Song, YY [1 ]
Jin, GZ [1 ]
机构：
[1] CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1996年 / 17卷 / 04期
关键词：
(-)-stepholidine; prolactin; radioimmunoassay; dopamine antagonists; pergolide;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To study the effect of (-)-stepholidine (SPD) on serum prolactin (PRL) level and elucidate its pharmacological action on,dopamine D-2 receptors. METHOD: After ip administration of dopamine receptor agonist, antagonist, or SPD, the serum PRL levels were determined by radioimmunoassay. RESULTS: SPD (24 mg . kg(-1), ip) caused a rapid rise in serum PRL level, lasting more than 1 h. SPD 0.2-40 mg . kg(-1) raised serum PRL level in a dose-dependent manner with ED(50) of 3.7 mg . kg(-1) (95 % confidence limits, 2.6-4.3 mg . kg(-1)) and PRL maximal level of 448 +/-64 mu g . L(-1). Pergolide 2 mg . kg(-1) ip caused a decrease (P < 0.01 vs saline) of PRL level, which was partially attenuated by SPD of 5 mg . kg(-1) and completely abolished by 10 mg . kg(-1). CONCLUSION: SPD is a dopamine D-2 receptor antagonist.
引用
收藏
页码：311 / 314
页数：4
相关论文
共 50 条
  • [21] Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine
    Watanabe, Moe
    Kopruszinski, Caroline M.
    Moutal, Aubin
    Ikegami, Daigo
    Khanna, Rajesh
    Chen, Yanxia
    Ross, Sarah
    Mackenzie, Kimberly
    Stratton, Jennifer
    Dodick, David W.
    Navratilova, Edita
    Porreca, Frank
    BRAIN, 2022, 145 (08) : 2894 - 2909
  • [22] CORRELATION STUDY OF SERUM PROLACTIN LEVELS, PITUITARY WEIGHTS, NUMBER AND ULTRASTRUCTURE OF PITUITARY LACTOTROPHS IN FEMALE LONG-EVANS RATS
    BAIRD, RE
    LOSINSKI, NE
    KOVACS, K
    THORNER, MO
    EXPERIMENTAL PATHOLOGY, 1990, 40 (02): : 95 - 103
  • [23] BEHAVIORAL ACTIONS OF PROLACTIN LOCALLY APPLIED INTO THE HIPPOCAMPUS OF ADULT FEMALE RATS
    ALVAREZ, EO
    BANZAN, AM
    JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1994, 95 (01) : 17 - 28
  • [24] Neuroanatomical specificity of prolactin-induced hyperphagia in virgin female rats
    Sauvé, D
    Woodside, B
    BRAIN RESEARCH, 2000, 868 (02) : 306 - 314
  • [25] Serum prolactin level in patients with multiple sclerosis: A case control study
    Harirchian, MH
    Sahraian, MA
    Shirani, A
    MEDICAL SCIENCE MONITOR, 2006, 12 (04): : CR177 - CR180
  • [26] The effect of routine breast examination on serum prolactin levels
    Hammond, KR
    Steinkampf, MP
    Boots, LR
    Blackwell, RE
    FERTILITY AND STERILITY, 1996, 65 (04) : 869 - 870
  • [27] The 'hook effect' on serum prolactin estimation in a patient with macroprolactinoma
    Unnikrishnan, AG
    Rajaratnam, S
    Seshadri, MS
    Kanagasapabathy, AS
    Stephen, DC
    NEUROLOGY INDIA, 2001, 49 (01) : 78 - 80
  • [28] An investigation of the association between the level of prolactin in serum and type II diabetes
    Manshaei, Najmeh
    Shakibaei, Feloria
    Fazilati, Mohammad
    Salavati, Hossein
    Negahdary, Masoud
    Palizban, Abbasali
    DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2019, 13 (05) : 3035 - 3041
  • [29] Effects of dopaminergic agonists and antagonists on the serum prolactin levels in alcoholized rats
    Samochowiec, J
    Kleinrok, Z
    JagielloWojtowicz, E
    Horodnicki, J
    Rommelspacher, H
    Schmidt, LG
    POLISH JOURNAL OF PHARMACOLOGY, 1997, 49 (04): : 221 - 227
  • [30] Seasonally dependent effect of ectopic pituitary grafts on 24-hour rhythms in serum prolactin and gonadotropins in rats
    Esquifino, AI
    Pazo, D
    Cutrera, RA
    Cardinali, DP
    CHRONOBIOLOGY INTERNATIONAL, 1999, 16 (04) : 451 - 460
12345