An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-γ-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene

被引：24

作者：

Liu, Peng ^{[1
]}

Lei, Min ^{[1
]}

Ma, Lei ^{[1
]}

Hu, Lihong ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

来源：

SYNLETT | 2011年 / 08期

基金：

中国国家自然科学基金;

关键词：

N-heterocyclic carbenes (NHCs); umpolung; cascade reaction; Stetter reaction; 2-aminofuran; CONJUGATE UMPOLUNG; BENZOIN REACTIONS; ALDEHYDES; ACYLOIN; TANDEM;

D O I：

10.1055/s-0030-1259945

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter-gamma-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed. This procedure provides the corresponding products in moderate to high yields under mild conditions.

引用

页码：1133 / 1136

页数：4

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