Optogenetics

被引：74
作者：
Duebel, Jens [1 ,2 ,3 ]
Marazova, Katia [1 ,2 ,3 ]
Sahel, Jose-Alain [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Univ Paris 06, Inst Vis, Sorbonne Univ, UMR S 968, Paris, France
[2] INSERM, U 968, Paris, France
[3] CNRS, UMR 7210, Paris, France
[4] Ctr Hosp Natl Ophtalmol Quinze Vingts, DHU ViewMaintain, INSERM, DHOS CIC 1423, Paris, France
[5] Fdn Ophtalmol Rothschild, Paris, France
[6] UCL, Inst Ophthalmol, London, England
来源：
CURRENT OPINION IN OPHTHALMOLOGY | 2015年 / 26卷 / 03期
基金：
欧洲研究理事会;
关键词：
optogenetic tools; retina; vision restoration; ADENOASSOCIATED VIRUS SEROTYPES; LEBERS CONGENITAL AMAUROSIS; RESTORES VISUAL RESPONSES; RETINAL GENE-THERAPY; RETINITIS-PIGMENTOSA; BIPOLAR CELLS; PHOTORECEPTOR DEGENERATION; HALOBACTERIUM-HALOBIUM; OPTICAL TECHNOLOGIES; ECTOPIC EXPRESSION;
D O I：
10.1097/ICU.0000000000000140
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose of review In this review, we will discuss the recent developments in optogenetics and their potential applications in ophthalmology to restore vision in retinal degenerative diseases. Recent findings In recent years, we have seen major advances in the field of optogenetics, providing us with novel opsins for potential applications in the retina. Microbial opsins with improved light sensitivity and red-shifted action spectra allow optogenetic stimulation at light levels well below the safety threshold in the human eye. In parallel, remarkable success in the development of highly efficient viral vectors for ocular gene therapy led to new strategies of using these novel optogenetic tools for vision restoration. Summary These recent findings show that novel optogenetic tools and viral vectors for ocular gene delivery are now available providing many opportunities to develop potential optogenetic strategies for vision restoration.
引用
收藏
页码：226 / 232
页数：7
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