Palladium(ii)-catalyzed -selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

被引：61

作者：

Matsuura, Rei ^{[1
]}

Jankins, Tanner C. ^{[1
]}

Hill, David E. ^{[1
]}

Yang, Kin S. ^{[1
]}

Gallego, Gary M. ^{[2
]}

Yang, Shouliang ^{[2
]}

He, Mingying ^{[2
]}

Wang, Fen ^{[2
]}

Marsters, Rohan P. ^{[1
]}

McAlpine, Indrawan ^{[2
]}

Engle, Keary M. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA

[2] Pfizer Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

来源：

CHEMICAL SCIENCE | 2018年 / 9卷 / 44期

基金：

美国国家卫生研究院;

关键词：

CATALYZED ASYMMETRIC 1,4-ADDITION; ARYL BORONIC ACIDS; UNACTIVATED ALKENES; CONJUGATE ADDITION; HECK ARYLATIONS; PALLADIUM; HYDROCARBOFUNCTIONALIZATION; 1,6-ADDITION; BENZOFURANS; REAGENTS;

D O I：

10.1039/c8sc03081b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic -selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(ii) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.

引用

页码：8363 / 8368

页数：6

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