TGF-β signaling and its targeting for glioma treatment

被引：3
作者：
Han, Jianfeng [1 ,2 ]
Alvarez-Breckenridge, Christopher A. [3 ]
Wang, Qi-En [2 ]
Yu, Jianhua [1 ,2 ]
机构：
[1] Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[3] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2015年 / 5卷 / 03期
基金：
美国国家卫生研究院;
关键词：
TGF-beta; TGF-beta signaling; glioma; gliomagenesis; glioma treatment; GROWTH-FACTOR-BETA; I KINASE INHIBITOR; GLIOBLASTOMA CELLS; MALIGNANT GLIOMAS; INITIATING CELLS; GAMMA PRODUCTION; NK CELLS; EXPRESSION; ANGIOGENESIS; CANCER;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine, secreted by a variety of cells including immune cells, tumor cells, and stromal cells. TGF-beta signaling is dysregulated in cancer patients, and this aberrant signaling at least in part contributes to initiation and progression of many cancers including glioma. The dysregulated signaling components provide molecular targets for the treatment of glioma. In this article, we review TGF-beta signaling and its targeting in glioma.
引用
收藏
页码：945 / 955
页数：11
相关论文
共 50 条
  • [21] Influence of thrombophlebitis on TGF-β1 and its signaling pathway in the vein wall
    Kowalewski, Radoslaw
    Malkowski, Andrzej
    Gacko, Marek
    Sobolewski, Krzysztof
    FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 2010, 48 (04) : 542 - 548
  • [22] Targeting the TGF-β signaling pathway for fibrosis therapy: a patent review (2015-2020)
    Li, Xuanyi
    Ding, Ziang
    Wu, Zixuan
    Xu, Yinqiu
    Yao, Hequan
    Lin, Kejiang
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2021, 31 (08) : 723 - 743
  • [23] TGF-β signaling in liver and gastrointestinal cancers
    Katz, L. H.
    Likhter, M.
    Jogunoori, W.
    Belkin, M.
    Ohshiro, K.
    Mishra, L.
    CANCER LETTERS, 2016, 379 (02) : 166 - 172
  • [24] Role of TGF-β signaling in uterine carcinosarcoma
    Dwivedi, Shailendra Kumar Dhar
    McMeekin, Scott D.
    Slaughter, Katrina
    Bhattacharya, Resham
    ONCOTARGET, 2015, 6 (16) : 14646 - 14655
  • [25] TGF-β signaling in fibrosis
    Biernacka, Anna
    Dobaczewski, Marcin
    Frangogiannis, Nikolaos G.
    GROWTH FACTORS, 2011, 29 (05) : 196 - 202
  • [26] SMAD7: a timer of tumor progression targeting TGF-β signaling
    Luo, Lingyu
    Li, Nianshuang
    Lv, Nonghua
    Huang, Deqiang
    TUMOR BIOLOGY, 2014, 35 (09) : 8379 - 8385
  • [27] Research progress on drugs targeting the TGF-β signaling pathway in fibrotic diseases
    Shi, Ning
    Wang, Zhihong
    Zhu, Hecheng
    Liu, Weidong
    Zhao, Ming
    Jiang, Xingjun
    Zhao, Jin
    Ren, Caiping
    Zhang, Yan
    Luo, Longlong
    IMMUNOLOGIC RESEARCH, 2022, 70 (03) : 276 - 288
  • [28] Processing of CD109 by furin and its role in the regulation of TGF-β signaling
    Hagiwara, S.
    Murakumo, Y.
    Mii, S.
    Shigetomi, T.
    Yamamoto, N.
    Furue, H.
    Ueda, M.
    Takahashi, M.
    ONCOGENE, 2010, 29 (15) : 2181 - 2191
  • [29] Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling
    Chung, Chih-Ling
    Tai, Shun-Ban
    Hu, Tsung-Hui
    Chen, Jih-Jung
    Chen, Chun-Lin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (16)
  • [30] Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy
    Lee, Ho-Jae
    JOURNAL OF CANCER PREVENTION, 2020, 25 (04) : 213 - 222
12345