TGF-β signaling and its targeting for glioma treatment

被引：3
作者：
Han, Jianfeng [1 ,2 ]
Alvarez-Breckenridge, Christopher A. [3 ]
Wang, Qi-En [2 ]
Yu, Jianhua [1 ,2 ]
机构：
[1] Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[3] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2015年 / 5卷 / 03期
基金：
美国国家卫生研究院;
关键词：
TGF-beta; TGF-beta signaling; glioma; gliomagenesis; glioma treatment; GROWTH-FACTOR-BETA; I KINASE INHIBITOR; GLIOBLASTOMA CELLS; MALIGNANT GLIOMAS; INITIATING CELLS; GAMMA PRODUCTION; NK CELLS; EXPRESSION; ANGIOGENESIS; CANCER;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine, secreted by a variety of cells including immune cells, tumor cells, and stromal cells. TGF-beta signaling is dysregulated in cancer patients, and this aberrant signaling at least in part contributes to initiation and progression of many cancers including glioma. The dysregulated signaling components provide molecular targets for the treatment of glioma. In this article, we review TGF-beta signaling and its targeting in glioma.
引用
收藏
页码：945 / 955
页数：11
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