Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

被引：7
|
作者：
Hladikova, Magdalena [1 ,2 ]
Vasku, Anna [3 ]
Stourac, Pavel [1 ,2 ]
Benesova, Yvonne [1 ,2 ]
Bednarik, Josef [1 ,2 ]
机构：
[1] Masaryk Univ, Dept Neurol, Fac Hosp Brno, Brno 62500, Czech Republic
[2] Masaryk Univ, Fac Med, Brno 62500, Czech Republic
[3] Masaryk Univ, Fac Med, Dept Pathol Physiol, Brno 66243, Czech Republic
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2011年 / 303卷 / 1-2期
关键词：
Multiple sclerosis; Angiotensin converting enzyme; Angiotensinogen; Polymorphism; Neuroinflammation; I-CONVERTING-ENZYME; INSERTION DELETION POLYMORPHISM; SPINAL-CORD; GENE; HYPERTENSION; PROMOTER; VARIANT; BRAIN;
D O I：
10.1016/j.jns.2011.01.020
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：31 / 34
页数：4
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