Green synthesis of bimetallic ZnO-CuO nanoparticles and their cytotoxicity properties

被引：102
作者：
Cao, Yan [1 ]
Dhahad, Hayder A. [2 ]
El-Shorbagy, M. A. [3 ,4 ]
Alijani, Hajar Q. [5 ]
Zakeri, Mana [6 ]
Heydari, Abolfazl [7 ]
Bahonar, Ehsan [8 ]
Slouf, Miroslav [9 ]
Khatami, Mehrdad [10 ]
Naderifar, Mahin [11 ]
Iravani, Siavash [12 ]
Khatami, Sanaz [13 ]
Dehkordi, Farnaz Farzaneh [14 ]
机构：
[1] Xian Technol Univ, Sch Mechatron Engn, Xian 710021, Peoples R China
[2] Univ Technol Baghdad, Dept Mech Engn, Baghdad, Iraq
[3] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Math, Al Kharj 11942, Saudi Arabia
[4] Menoufia Univ, Dept Basic Engn Sci, Fac Engn, Shibin Al Kawm 32511, Egypt
[5] Shahid Bahonar Univ Kerman, Dept Biotechnol, Kerman, Iran
[6] Islamic Azad Univ, Tehran Med Branch, Dept Biol, Tehran, Iran
[7] Slovak Acad Sci, Polymer Inst, Dubravska Cesta 9, Bratislava 84541, Slovakia
[8] Sahand Univ Technol, Fac Chem & Petr Engn, Tabriz, Iran
[9] Czech Acad Sci, Inst Macromol Chem, Heyrovskeho Nam 2, Prague 16206 6, Czech Republic
[10] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran
[11] Zabol Univ Med Sci, Fac Nursing & Midwifery, Zabol, Iran
[12] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Esfahan, Iran
[13] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran
[14] Islamic Azad Univ, Ardabil Branch, Dept Biol, Ardebil, Iran
来源：
SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期
关键词：
OXIDE NANOPARTICLES; IN-VITRO; ANTICANCER; BIOSYNTHESIS; COPPER; ANTIOXIDANT; MELANOMA; EXTRACT; CELLS; MCF-7;
D O I：
10.1038/s41598-021-02937-1
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low.
引用
收藏
页数：8
相关论文
共 64 条
  • [1] Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells
    Ahamed, Maqusood
    Siddiqui, Maqsood A.
    Akhtar, Mohd J.
    Ahmad, Iqbal
    Pant, Aditya B.
    Alhadlaq, Hisham A.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 396 (02) : 578 - 583
  • [2] Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications
    Alijani, Hajar Q.
    Iravani, Siavash
    Pourseyedi, Shahram
    Torkzadeh-Mahani, Masoud
    Barani, Mahmood
    Khatami, Mehrdad
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [3] Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review
    Amiri, Mohammad Sadegh
    Mohammadzadeh, Vahideh
    Yazdi, Mohammad Ehsan Taghavizadeh
    Barani, Mahmood
    Rahdar, Abbas
    Kyzas, George Z.
    [J]. MOLECULES, 2021, 26 (06):
  • [4] COVID-19 in people with diabetes: understanding the reasons for worse outcomes
    Apicella, Matteo
    Campopiano, Maria Cristina
    Mantuano, Michele
    Mazoni, Laura
    Coppelli, Alberto
    Prato, Stefano Del
    [J]. LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (09) : 782 - 792
  • [5] Simulation, In Vitro, and In Vivo Cytotoxicity Assessments of Methotrexate-Loaded pH-Responsive Nanocarriers
    Barani, Mahmood
    Reza Hajinezhad, Mohammad
    Sargazi, Saman
    Zeeshan, Mahira
    Rahdar, Abbas
    Pandey, Sadanand
    Khatami, Mehrdad
    Zargari, Farshid
    [J]. POLYMERS, 2021, 13 (18)
  • [6] Nanodiagnosis and nanotreatment of colorectal cancer: an overview
    Barani, Mahmood
    Bilal, Muhammad
    Rahdar, Abbas
    Arshad, Rabia
    Kumar, Arun
    Hamishekar, Hamed
    Kyzas, George Z.
    [J]. JOURNAL OF NANOPARTICLE RESEARCH, 2021, 23 (01)
  • [7] Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections
    Barani, Mahmood
    Mukhtar, Mahwash
    Rahdar, Abbas
    Sargazi, Ghasem
    Thysiadou, Anna
    Kyzas, George Z.
    [J]. MOLECULES, 2021, 26 (01):
  • [8] Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates
    Barani, Mahmood
    Sabir, Fakhara
    Rahdar, Abbas
    Arshad, Rabia
    Kyzas, George Z.
    [J]. NANOMATERIALS, 2020, 10 (09) : 1 - 25
  • [9] A new formulation of hydrophobin-coated niosome as a drug carrier to cancer cells
    Barani, Mahmood
    Mirzaei, Mohammad
    Torkzadeh-Mahani, Masoud
    Lohrasbi-Nejad, Azadeh
    Nematollahi, Mohammad Hadi
    [J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 113 (113):
  • [10] Evaluation of Carum-loaded Niosomes on Breast Cancer Cells:Physicochemical Properties, In Vitro Cytotoxicity, Flow Cytometric, DNA Fragmentation and Cell Migration Assay
    Barani, Mahmood
    Mirzaei, Mohammad
    Torkzadeh-Mahani, Masoud
    Adeli-sardou, Mahboubeh
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
1234567