Green synthesis of bimetallic ZnO-CuO nanoparticles and their cytotoxicity properties

被引：115

作者：

Cao, Yan ^{[1
]}

Dhahad, Hayder A. ^{[2
]}

El-Shorbagy, M. A. ^{[3
,4
]}

Alijani, Hajar Q. ^{[5
]}

Zakeri, Mana ^{[6
]}

Heydari, Abolfazl ^{[7
]}

Bahonar, Ehsan ^{[8
]}

Slouf, Miroslav ^{[9
]}

Khatami, Mehrdad ^{[10
]}

Naderifar, Mahin ^{[11
]}

Iravani, Siavash ^{[12
]}

Khatami, Sanaz ^{[13
]}

Dehkordi, Farnaz Farzaneh ^{[14
]}

机构：

[1] Xian Technol Univ, Sch Mechatron Engn, Xian 710021, Peoples R China

[2] Univ Technol Baghdad, Dept Mech Engn, Baghdad, Iraq

[3] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Math, Al Kharj 11942, Saudi Arabia

[4] Menoufia Univ, Dept Basic Engn Sci, Fac Engn, Shibin Al Kawm 32511, Egypt

[5] Shahid Bahonar Univ Kerman, Dept Biotechnol, Kerman, Iran

[6] Islamic Azad Univ, Tehran Med Branch, Dept Biol, Tehran, Iran

[7] Slovak Acad Sci, Polymer Inst, Dubravska Cesta 9, Bratislava 84541, Slovakia

[8] Sahand Univ Technol, Fac Chem & Petr Engn, Tabriz, Iran

[9] Czech Acad Sci, Inst Macromol Chem, Heyrovskeho Nam 2, Prague 16206 6, Czech Republic

[10] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran

[11] Zabol Univ Med Sci, Fac Nursing & Midwifery, Zabol, Iran

[12] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Esfahan, Iran

[13] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

[14] Islamic Azad Univ, Ardabil Branch, Dept Biol, Ardebil, Iran

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

OXIDE NANOPARTICLES; IN-VITRO; ANTICANCER; BIOSYNTHESIS; COPPER; ANTIOXIDANT; MELANOMA; EXTRACT; CELLS; MCF-7;

D O I：

10.1038/s41598-021-02937-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low.

引用

页数：8

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