Telomeric recombination induced by dysfunctional telomeres

被引：22

作者：

Brault, Marie Eve ^{[1
,2
]}

Autexier, Chantal ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2B2, Canada

[2] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Bloomfield Ctr Res Aging, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Med, Div Expt Med, Montreal, PQ H3A 2B2, Canada

来源：

MOLECULAR BIOLOGY OF THE CELL | 2011年 / 22卷 / 02期

基金：

加拿大健康研究院;

关键词：

HUMAN CANCER-CELLS; ABERRANT HOMOLOGOUS RECOMBINATION; IMMORTAL HUMAN-CELLS; MUTANT TELOMERASE; TUMOR-CELLS; ALT CELLS; PML BODY; DNA; MAINTENANCE; TEMPLATE;

D O I：

10.1091/mbc.E10-02-0173

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that recombination-based telomere maintenance can be activated after telomerase inhibition. We determined whether telomeric recombination can also be promoted by telomere dysfunction. We report for the first time that telomeric recombination can be induced in human telomerase-positive cancer cells with dysfunctional telomeres.

引用

页码：179 / 188

页数：10

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