Reaction of Dimethyl Trisulfide with Hemoglobin

被引：7

作者：

Dong, Xinmei ^{[1
]}

Kiss, Lorand ^{[1
,2
]}

Petrikovics, Ilona ^{[1
]}

Thompson, David E. ^{[1
]}

机构：

[1] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA

[2] Univ Szeged, Dept Pathophysiol, H-6720 Szeged, Hungary

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2017年 / 30卷 / 09期

关键词：

CYANIDE; MECHANISM; BLOOD;

D O I：

10.1021/acs.chemrestox.7b00181

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dimethyl trisulfide (DMTS) is a promising antidotal candidate for cyanide intoxication. DMTS acts as a sulfur donor in the conversion of cyanide to the less-toxic thiocyanate. The alternate reaction pathways of DMTS in the blood are not well understood. We report changes in the hemoglobin absorption spectrum upon reaction with DMTS. These changes closely match those induced by the known methemoglobin former, sodium nitrite. The kinetics of methemoglobin formation with DMTS is slower than with sodium nitrite. These results support the hypothesis that a potentially significant side-reaction of the therapeutically administered DMTS is the oxidization of hemoglobin to methemoglobin.

引用

页码：1661 / 1663

页数：3

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