Does the gut microbiota control our brain?

被引：0

作者：

Fond, Guillaume ^{[1
]}

机构：

[1] Fac Aix Marseille Secteur Timone, Lab Sante Publ, 27 Blvd Jean Moulin, F-13005 Marseille, France

来源：

ANNALES MEDICO-PSYCHOLOGIQUES | 2018年 / 176卷 / 08期

关键词：

Brain; Central nervous system; Disease of the digestive system; Drug Therapy; Intestinal microbiota; Intestine; Microbiology; Psychiatric pathology; IRRITABLE-BOWEL-SYNDROME; AUTISM SPECTRUM DISORDERS; BIPOLAR DISORDER; REGRESSIVE AUTISM; WEIGHT-GAIN; LACTOBACILLUS-HELVETICUS; INTESTINAL MICROBIOTA; CYTOKINE ALTERATIONS; PROBIOTIC TREATMENT; IMMUNE ACTIVATION;

D O I：

10.1016/j.amp.2018.08.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

While forecasts predict an increase in the prevalence of mental health disorders in the worldwide general population, the response rate to classical psychiatric treatment remains unsatisfactory. Resistance to psychotropic drugs can be due to clinical, pharmacological, pharmacokinetic, and pharmacodynamic factors. Among these factors, recent animal findings suggest that microbiota may have an underestimated influence on its host's behavior and on drug metabolism that may explain ineffectiveness or increased side effects of psychiatric medications such as weight gain. The following issues were identified in the present review: (i) microbiota dysbiosis and putative consequences on central nervous system functioning, (ii) chronic microbiota dysbiosis-associated illnesses in humans. (C) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：824 / 830

页数：7

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