The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family

被引：128

作者：

Cartwright, R ^{[1
]}

Tambini, CE ^{[1
]}

Simpson, PJ ^{[1
]}

Thacker, J ^{[1
]}

机构：

[1] MRC, Radiat & Genome Stabil Unit, Harwell OX11 0RD, Oxon, England

来源：

NUCLEIC ACIDS RESEARCH | 1998年 / 26卷 / 13期

关键词：

D O I：

10.1093/nar/26.13.3084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We recently identified a positional candidate for the XRCC2 DNA repair gene at human chromosome 7q36.1, We have now cloned the cDNA for this gene from both human and mouse and show that it is a highly conserved novel member of the recA/RAD51 recombination repair gene family. The cDNA is able to complement significantly the phenotype of a unique cell line, irs1, which shows extreme sensitivity to DNA cross-linking agents and genetic instability. This phenotype is consistent with a role for the XRCC2 gene in recombination repair in somatic cells, suggesting that in addition to RAD51, other members of this gene family have an important function in high fidelity repair processes in mammals. Despite this function, the XRCC2 gene transcript is expressed at a very low level in somatic tissue, but is elevated in mouse testis, suggesting an additional role in meiosis.

引用

页码：3084 / 3089

页数：6