Study of in vitro cytotoxic performance of biosynthesized a-Bi2O3 NPs, Mn-doped and Zn-doped Bi2O3 NPs against MCF-7 and HUVEC cell lines

被引：29

作者：

Sarani, Mina ^{[1
]}

Tosan, Foad ^{[2
]}

Hasani, Sadegh Abaei ^{[3
]}

Barani, Mahmood ^{[4
]}

Adeli-Sardou, Mahboubeh ^{[5
,6
]}

Khosravani, Masood ^{[8
]}

Niknam, Sedigheh ^{[7
]}

Kouhbanani, Mohammad Amin Jadidi ^{[8
]}

Beheshtkhoo, Nasrin ^{[8
]}

机构：

[1] Zabol Univ Med Sci, Zabol Med Plants Res Ctr, Zabol, Iran

[2] Semnan Univ Med Sci, Student Res Comm, Semnan, Iran

[3] Univ Med Shahid Beheshti, Fac Canc Res Ctr, Dept Gen Surg, Tehran, Iran

[4] Kerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran

[5] Kerman Univ Med Sci, Herbal & Tradit Med Res Ctr, Kerman, Iran

[6] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Dept Biotechnol, Kerman, Iran

[7] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran

[8] Univ Kashan, Nanosci & Nanotechnol, Kashan, Iran

来源：

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | 2022年 / 19卷

关键词：

Doped Bi2O3 NPs; Umbilical vein endothelial; MCF-7; a-Bi(2)O(3)NPs; Green synthesis; GREEN SYNTHESIS; NANOPARTICLES; CANCER;

D O I：

10.1016/j.jmrt.2022.05.002

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Green-synthesized nanoparticles can be applicable in designing an effective, efficient, and low-risk treatment for cancer. In this regard, we introduced a novel and eco-friendly method for preparing pure alpha-Bi2O3, Mn-doped Bi2O3, and Zn-doped Bi2O3 nanoparticles with potent cytotoxic activity through the application of Salvadora persica extract as the green reactive, reducing, and capping agent. The biosynthesis and characterization of our product was supported by the results of powder X-ray Powder Diffraction (PXRD), Energy Dispersive X-Ray (EDAX), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared (FT-IR), and Raman analysis. The outcomes of SEM analysis displayed the porous morphology of pure alpha-Bi2O3 nanoparticles, whereas the doping of Zn and Mn turned their structure into a conical shape. The TEM results presented the hexagonal shape of pure alpha-Bi2O3 NPs with a particle size mean of 46 nm. Additionally, the Zn-doped Bi2O3 nanoparticles consisted spherical particles with 32 nm of size mean, while the Mn-doped Bi2O3 NPs were approximately hexagonal with a particle size mean of 41 nm. The success of doping process was proven by the EDX analysis. Next to their high potential in cytotoxic performance against cancer cell line, the results of MTT assay confirmed the potent cytotoxic activity of synthesized nanoparticles against breast cancer (MCF-7) and human umbilical vein endothelial (HUVEC) cells as well. Considering these observations, these products can be suggested as a proper candidate for biological and medical applications. (C) 2022 The Author(s). Published by Elsevier B.V.

引用

页码：140 / 150

页数：11

共 47 条

[1] Facile Synthesis of Zn-Doped Bi2O3 Nanoparticles and Their Selective Cytotoxicity toward Cancer Cells [J].