Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention

被引：13

作者：

Adam, Tanja C. ^{[1
]}

Drummen, Mathijs ^{[1
,2
]}

Macdonald, Ian ^{[3
]}

Jalo, Elli ^{[4
]}

Siig-Vestentoft, Pia ^{[5
]}

Martinez, J. Alfredo ^{[6
,7
,8
,9
,10
]}

Handjiev-Darlenska, Teodora ^{[11
]}

Brand-Miller, Jennie ^{[12
,13
]}

Poppitt, Sally ^{[14
]}

Stratton, Gareth ^{[15
]}

Fogelholm, Mikael ^{[4
]}

Pietilainen, Kirsi H. ^{[16
,17
,18
]}

Taylor, Moira ^{[2
,3
]}

Navas-Carretero, Santiago ^{[6
,7
,8
]}

Winkens, Bjorn ^{[19
]}

Handjiev, Svetoslav ^{[11
]}

Muirhead, Roslyn ^{[12
,13
]}

Silvestre, Marta ^{[14
,20
]}

Swindell, Nils ^{[15
]}

Huttunen-Lenz, Maija ^{[21
,22
]}

Schlicht, Wolfgang ^{[21
]}

Lam, Tony ^{[23
]}

Sundvall, Jouko ^{[24
]}

Raman, Laura ^{[24
]}

Feskens, Edith ^{[25
]}

Larssen, Thomas-Meinert ^{[5
]}

Tremblay, Angelo ^{[26
]}

Raben, Anne ^{[5
,27
]}

Westerterp-Plantenga, Margriet ^{[1
]}

机构：

[1] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Nutr & Movement Sci, Maastricht, Netherlands

[2] Univ Nottingham, ARUK Ctr Sport Exercise & Osteoarthritis, Arthrit Res UK ARUK Ctr Musculoskeletal Ageing, MRC, Nottingham, England

[3] Queens Med Ctr, Natl Inst Hlth Res, Div Physiol Pharmacol & Neurosci, Nottingham Biomed Res Ctr,Sch Life Sci, Nottingham, England

[4] Univ Helsinki, Dept Food & Nutr, Helsinki, Finland

[5] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark

[6] Univ Navarra, Ctr Nutr Res, Pamplona, Spain

[7] Ctr Invest Biomed Red Area Fisiol Obesidad & Nutr, Madrid, Spain

[8] IdisNA Inst Hlth Res, Pamplona, Spain

[9] Univ Autonoma Madrid, Madrid Inst Adv Studies, IMDEA Food Inst, Precis Nutr & Cardiometab Hlth Program, Campus Int Excellence, Madrid, Spain

[10] Spanish Natl Res Council, Madrid, Spain

[11] Med Univ Sofia, Dept Pharmacol & Toxicol, Sofia, Bulgaria

[12] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia

[13] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia

[14] Univ Auckland, Dept Med, Sch Biol Sci, Human Nutr Unit, Auckland, New Zealand

[15] Swansea Univ, Coll Engn, Appl Sports Technol Exercise & Med Res Ctr, Swansea, W Glam, Wales

[16] Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Obes Res Unit, Helsinki, Finland

[17] Helsinki Univ Hosp, Abdominal Ctr, Obes Ctr, Helsinki, Finland

[18] Univ Helsinki, Helsinki, Finland

[19] Maastricht Univ, Med Ctr, Care & Publ Hlth Res Inst, Dept Methodol & Stat, Maastricht, Netherlands

[20] NOVA Univ Lisbon, NOVA Med Sch, Ctr Invest Tecnol & Serv Saude, Lisbon, Portugal

[21] Univ Stuttgart, Exercise & Hlth Sci, Stuttgart, Germany

[22] Univ Educ Schwabisch Gmund, Inst Nursing Sci, Schwabisch Gmund, Germany

[23] NetUnion, Lausanne, Switzerland

[24] Natl Inst Hlth & Welf, Dept Govt Serv, Forens Toxicol Unit, Biochem Lab, Helsinki, Finland

[25] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands

[26] Laval Univ, Dept Kinesiol, Quebec City, PQ, Canada

[27] Steno Diabet Ctr Copenhagen, Copenhagen, Denmark

来源：

DIABETES CARE | 2021年 / 44卷 / 07期

基金：

英国工程与自然科学研究理事会; 芬兰科学院; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

WEIGHT-LOSS; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; STRESS; OBESITY; QUESTIONNAIRE; MAINTENANCE; ADULTS;

D O I：

10.2337/dc21-0059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE Stress, sleep, eating behavior, and physical activity are associated with weight change and insulin resistance (IR). The aim of this analysis was the assessment of the overall and sex-specific associations of psychobehavioral variables throughout the 3-year PREVIEW intervention using the homeostatic model assessment of IR (HOMA-IR), BMI, and length of time in the study. RESEARCH DESIGN AND METHODS Associations of psychobehavioral variables, including stress, mood, eating behavior, physical activity (PA), and sleep, with BMI, HOMA-IR, and time spent in the study were assessed in 2,184 participants with prediabetes and overweight/obesity (n = 706 men; n = 1,478 women) during a 3-year lifestyle intervention using linear mixed modeling and general linear modeling. The study was a randomized multicenter trial using a 2 x 2 diet-by-PA design. RESULTS Overall, cognitive restraint and PA increased during the intervention compared with baseline, whereas BMI, HOMA-IR, disinhibition, hunger, and sleepiness decreased (all P < 0.05). Cognitive restraint and PA were negatively, whereas disinhibition, hunger, stress, and total mood disturbance were positively, associated with both BMI and HOMA-IR. Sleep duration, low sleep quality, total mood disturbance, disinhibition, and hunger scores were positively associated with HOMA-IR for men only. Participants who dropped out at 6 months had higher stress and total mood disturbance scores at baseline and throughout their time spent in the study compared with study completers. CONCLUSIONS Eating behavior and PA, control of stress, mood disturbance, and sleep characteristics were associated with BMI, HOMA-IR, and time spent in the study, with different effects in men and women during the PREVIEW lifestyle intervention study.

引用

页码：1491 / 1498

页数：8

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