Preparation and evaluation of shikonin ointment for wound healing - Effectiveness in an experimental wound healing model in rats

被引：0
|
作者：
Sekine, T
Kojima, K
Ota, S
Matsumoto, T
Yamamoto, T
Maitani, Y
Nagai, T
机构：
[1] Tsumura & Co, Cent Res Labs, Dept Pharmaceut Technol, Ami, Ibaraki 3001192, Japan
[2] Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan
来源：
STP PHARMA SCIENCES | 1998年 / 8卷 / 04期
关键词：
shikonin; ointment; macrogol; wound healing; deep burn; open wound;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Shikonin ointment was prepared Sor wound healing and its enhancing effect on wound healing was evaluated by using an experimental burn and open wound healing model in rats. The concentrations of shikonin were 0.1 and 0.5% in a macrogol base. Shikonin ointments had an enhancing effect on wound healing in the experimental burn and open wound healing models. Shikonin ointments had an anti-inflammatory effect on the experimental open wound healing model. The 0.1 % shikonin concentration was effective and the shikonin ointment was more effective on wound healing than a commercial preparation.
引用
收藏
页码：249 / 253
页数：5
相关论文
共 50 条
  • [41] OINTMENT OF METHANOLIC EXTRACT OF FICUS RELIGIOSA: A TRADITIONAL APPROACH IN WOUND HEALING IN RATS
    Gupta, Reena
    Gupta, Jitendra
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (12): : 5006 - 5011
  • [42] THE HEALING WOUND IN EXPERIMENTAL DIABETES
    ROSEN, RG
    ENQUIST, IF
    SURGERY, 1961, 50 (03) : 525 - 528
  • [43] ANTICOAGULANTS AND EXPERIMENTAL WOUND HEALING
    ZAHIR, M
    BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY, 1965, 46 (06): : 623 - &
  • [44] EXPERIMENTAL WOUND HEALING IN MAN
    RAMIREZ, AT
    SOROFF, HS
    SCHWARTZ, MS
    MOOTY, J
    PEARSON, E
    RABEN, MS
    SURGERY GYNECOLOGY AND OBSTETRICS WITH INTERNATIONAL ABSTRACTS OF SURGERY, 1969, 128 (02): : 283 - +
  • [45] Healing Effect of Sesame Ointment on Second-degree Burn Wound in Rats
    Tehrani, Setareh
    Lotfi, Parisa
    Tehrani, Sepideh
    Jangholi, Ehsan
    Aryan, Hoda
    Aidun, Amir
    GALEN MEDICAL JOURNAL, 2016, 5 (02): : 56 - 62
  • [46] WOUND HEALING IN EXPERIMENTAL LATHYRISM
    ENZINGER, FM
    WARNER, ED
    LABORATORY INVESTIGATION, 1957, 6 (03) : 251 - 258
  • [47] Evaluation of wound healing effects between Salvadora persica ointment and Solcoseryl jelly in animal model
    Imran, Hina
    Ahmad, Mansoor
    Atiq-ur-Rahman
    Yaqeen, Zahra
    Sohail, Tehmina
    Fatima, Nudrat
    Iqbal, Wasif
    Yaqeen, Syed Shafay
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 28 (05) : 1777 - 1780
  • [48] Evaluation of the effect of topical Silymarin ointment on wound healing in a rat model under heat stress
    Aliabadi, A.
    Farahmand, M.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2009, 32 : 167 - 167
  • [49] Evaluation of Wound Healing Effect of Topical Phenytoin on Excisional Wound in Albino Rats
    Hasamnis, A. A.
    Mohanty, B. K.
    Muralikrishna
    Patil, S.
    JOURNAL OF YOUNG PHARMACISTS, 2010, 2 (01) : 50 - 57
  • [50] EVALUATION OF THE WOUND HEALING ACTIVITY OF COMMELINA BENGHALENSIS LEAVES EXTRACT IN EXPERIMENTAL RATS
    Joshi, Om Prakash
    Singh, Balwan
    Singh, D. C. P.
    INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2019, 9 (04): : P14 - P18
12345