Recent developments in chitosan hydrogels carrying natural bioactive compounds

被引：141
作者：
Do, Nga H. N. [1 ,2 ]
Truong, Quyen T. [1 ,2 ]
Le, Phung K. [1 ,2 ,3 ]
Ha, Anh C. [1 ,2 ,3 ]
机构：
[1] Ho Chi Minh City Univ Technol HCMUT, Fac Chem Engn, 268 Ly Thuong Kiet St, Ho Chi Minh City, Vietnam
[2] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Linh Trung Ward, Ho Chi Minh City, Vietnam
[3] Ho Chi Minh City Univ Technol HCMUT, Fac Chem Engn, Ho Chi Minh City, Vietnam
来源：
CARBOHYDRATE POLYMERS | 2022年 / 294卷
关键词：
Chitosan hydrogel; Natural extracts; Fabrication; Bioactivity; Controlled drug delivery; CONTROLLED-RELEASE; DRUG-DELIVERY; THERMOSENSITIVE HYDROGEL; ZINC-OXIDE; EXTRACT; SUNSCREENS; SYSTEM; BONE; NANOPARTICLES; CONSTITUENTS;
D O I：
10.1016/j.carbpol.2022.119726
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Chitosan hydrogel is a smart and highly applicable drug delivery carrier because of its nature, biocompatibility, biodegradability, and ability to encapsulate, carry and release the drug to the desired target flexibly depending on the conditions of the patient. Not only developing delivery systems but natural compounds are also increasingly being studied in supporting the treatment of diseases. However, the physicochemical and pharmacokinetic issues of the phytochemicals are remaining. This review summarizes the remarkable properties of chitosan hydrogel; approaches to loading natural extracts on the hydrogels to overcome the susceptibility of the phytochemicals to degradation; and their applications in biomedical fields. The drug loading efficiency, release profile, in vitro and in vivo results of the chitosan hydrogels carrying natural compounds are discussed to point out the remaining challenges of combining the extracts with chitosan hydrogels and controlling the release of the carried substances.
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页数：16
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