Artificial neural networks reveal sex differences in gene methylation, and connections between maternal risk factors and symptom severity in autism spectrum disorder

被引：9

作者：

Stoccoro, Andrea ^{[1
]}

Gallo, Roberta ^{[1
]}

Calderoni, Sara ^{[2
,3
]}

Cagiano, Romina ^{[2
]}

Muratori, Filippo ^{[2
,3
]}

Migliore, Lucia ^{[1
]}

Grossi, Enzo ^{[4
]}

Coppede, Fabio ^{[1
]}

机构：

[1] Univ Pisa, Med Sch, Dept Translat Res & New Surg & Med Technol, Via Roma 55, I-56126 Pisa, Italy

[2] IRCCS Stella Maris Fdn, I-56128 Pisa, Italy

[3] Univ Pisa, Dept Clin & Expt Med, Via Roma 55, I-56126 Pisa, Italy

[4] Villa Santa Maria Fdn, I-22038 Como, Italy

来源：

EPIGENOMICS | 2022年 / 14卷 / 19期

关键词：

artificial neural networks; ASD; autism spectrum disorder; DNA methylation; epigenetics; maternal risk factors; sex difference; DNA METHYLATION; PROMOTER METHYLATION; PERIPHERAL-BLOOD; FRONTAL-CORTEX; BRAIN; BDNF; RELN; PREDICTORS; BIOMARKER; SYSTEM;

D O I：

10.2217/epi-2022-0179

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim and methods: Artificial neural networks were used to unravel connections among blood gene methylation levels, sex, maternal risk factors and symptom severity evaluated using the Autism Diagnostic Observation Schedule 2 (ADOS-2) score in 58 children with autism spectrum disorder (ASD). Results: Methylation levels of MECP2, HTR1A and OXTR genes were connected to females, and those of EN2, BCL2 and RELN genes to males. High gestational weight gain, lack of folic acid supplements, advanced maternal age, preterm birth, low birthweight and living in rural context were the best predictors of a high ADOS-2 score. Conclusion: Artificial neural networks revealed links among ASD maternal risk factors, symptom severity, gene methylation levels and sex differences in methylation that warrant further investigation in ASD.

引用

页码：1181 / 1195

页数：16

共 80 条

[1] Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients:: A preliminary report [J].

Abdolmaleky, HM ;

Cheng, KH ;

Russo, A ;

Smith, CL ;

Faraone, SV ;

Wilcox, M ;

Shafa, R ;

Glatt, SJ ;

Nguyen, G ;

Ponte, JF ;

Thiagalingam, S ;

Tsuang, MT .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 134B (01) :60-66

[2] Methylation of the Reelin Gene Promoter in Peripheral Blood and Its Relationship with the Cognitive Function of Schizophrenia Patients [J].

Alfimova, M. V. ;

Kondratiev, N. V. ;

Golov, A. K. ;

Golimbet, V. E. .

MOLECULAR BIOLOGY, 2018, 52 (05) :676-685

[3]

Alfimova M V, 2018, Zh Nevrol Psikhiatr Im S S Korsakova, V118, P71, DOI 10.17116/jnevro201811809171

[4] Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults [J].

Alvarez-Fischer, Daniel ;

Fuchs, Julia ;

Castagner, Francois ;

Stettler, Olivier ;

Massiani-Beaudoin, Olivia ;

Moya, Kenneth L. ;

Bouillot, Colette ;

Oertel, Wolfgang H. ;

Lombes, Anne ;

Faigle, Wolfgang ;

Joshi, Rajiv L. ;

Hartmann, Andreas ;

Prochiantz, Alain .

NATURE NEUROSCIENCE, 2011, 14 (10) :1260-U182

[5]

American Psychiatric Association, 2013, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425596

[6] Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity [J].

Andari, Elissar ;

Nishitani, Shota ;

Kaundinya, Gopinath ;

Caceres, Gabriella A. ;

Morrier, Michael J. ;

Ousley, Opal ;

Smith, Alicia K. ;

Cubells, Joseph F. ;

Young, Larry J. .

NEUROPSYCHOPHARMACOLOGY, 2020, 45 (07) :1150-1158

[7]

[Anonymous], 2022, Autism Spectrum Disorders

[8]

[Anonymous], 2018, Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, V70, P1, DOI [DOI 10.15585/MMWR.SS7011A1, 10.15585/mmwr.ss7011a1external icon, DOI 10.15585/MMWR.SS7202A1]

[9] Reelin: Diverse roles in central nervous system development, health and disease [J].

Armstrong, Nicholas C. ;

Anderson, Rebecca C. ;

McDerrnott, Kieran W. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2019, 112 :72-75

[10] Advanced Maternal Age and the Risk of Cesarean Birth: A Systematic Review [J].

Bayrampour, Hamideh ;

Heaman, Maureen .

BIRTH-ISSUES IN PERINATAL CARE, 2010, 37 (03) :219-226

← 1 2 3 4 5 6 7 8 →